Antimicrobial Activity of Fourth Generation Fluoroquinolone Soaked Acrylic Intraocular Lenses

Abstract

Purpose:: To determine if Acrysof ^® SA 60 Intraocular lenses (IOL) soaked in Moxifloxacin 0.5% or Gatifloxacin 0.3% for one minute have antimicrobial properties.

Methods:: Ten (10) Alcon ® SA60 acrylic intraocular lenses were soaked in Moxifloxacin 0.5%, Ten (10) were soaked in Gatifloxacin 0.3% and Ten (10) in normal saline. Each IOL was soaked for one minute then dried.The IOL’s were plated on Mueller Hinton agar with quality controlled ATCC 25923 Staphylococcus aureus overlay.

Results:: All antibiotic soaked IOL’s had kill zones as compared to no kill zones for the normal saline soaked lenses. A comparison of condition means was performed using repeated measure ANOVA which was found to be highly significant P<0.001. The Gatifloxacin soaked lens kill zones were significantly less then the moxifloxacin kill zones P<0.011.

Conclusions:: Acrysof SA60 IOL’s soaked in commercially available fourth generation Fluoroquinolones for one minute have antimicrobial activity. Moxifloxacin 0.5% had a y significantly greater kill zone area than Gatifloxacin 0.3%.

Keywords: endophthalmitis • antibiotics/antifungals/antiparasitics • cataract