May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Correlation Between Physico-Chemical Parameters and Performance of Ophthalmic Viscosurgical Devices (OVD) During Cataract Surgery in Animal Eyes
Author Affiliations & Notes
  • B. O. Lundgren
    Advanced Medical Optics, Uppsala, Sweden
  • R. Bergman
    Advanced Medical Optics, Uppsala, Sweden
  • M. Lundqvist
    Advanced Medical Optics, Uppsala, Sweden
  • S. Mannberg
    Advanced Medical Optics, Uppsala, Sweden
  • R. Shimizu
    Advanced Medical Optics, Santa Ana, California
  • R. Steinert
    University of California, Irvine, California
  • Footnotes
    Commercial Relationships B.O. Lundgren, Advanced Medical Optics, E; R. Bergman, Advanced Medical Optics, E; M. Lundqvist, Advanced Medical Optics, E; S. Mannberg, Advanced Medical Optics, E; R. Shimizu, Advanced Medical Optics, E; R. Steinert, Advanced Medical Optics, C.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1069. doi:
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      B. O. Lundgren, R. Bergman, M. Lundqvist, S. Mannberg, R. Shimizu, R. Steinert; Correlation Between Physico-Chemical Parameters and Performance of Ophthalmic Viscosurgical Devices (OVD) During Cataract Surgery in Animal Eyes. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1069.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: Phacoemulsification with use of an OVD is the preferred technique of modern cataract surgery. The OVD maintain the anterior chamber, protects the corneal endothelium and facilitates IOL implantation. The clinical impression is that dispersive OVDs retain in the anterior chamber and protect the endothelium better during phacoemulsification than cohesive OVDs. The purpose with this study was to correlate physico-chemical parameters of different OVDs with their performance (anterior chamber maintenance and retention) at different stages of the surgical procedure.

Methods:: The physico-chemical parameter cross over frequency of the OVDs (when elastic and viscous properties are equal) was determined using a rheometer using oscillatory test methods.For the ex vivo experiment fresh eyes from newly slaughtered pigs were used. Anterior chamber depth (ACD) was measured using a NIDEK-1000 scheimpflug camera. Images were obtained before surgery, after injection of OVD, after capsulorhexis and finally after crystalline lens removal using phacoemulsification. For each product investigated at least eight eyes were used. Products tested were Healon, Healon GV, Healon5, Provisc, Viscoat, Discovisc and Amvisc Plus.

Results:: Cross over frequency was higher for low molecular mass dispersive products and lower for high molecular mass cohesive products. The cohesive products showed a better anterior maintenance capacity for filling and capsulorhexis while the dispersive products showed a better retention capacity during phacoemulsification. One product, the viscoadaptive cohesive Healon5, showed the best anterior maintenance capacity for the early stages of the surgical procedure and also retained in the eye to the same extent as the dispersive products.

Conclusions:: Selection of OVDs for existing and novel surgical procedures should balance the use of rheological data and ex vivo analyses. Using these approaches, surgeons can optimize their selection of OVDs to meet the demands of surgical procedures.

Keywords: cataract • injection 

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