May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Effect of Memantine and Gabapentin on Changes in Nystagmus Waveform in Congenital Nystagmus
Author Affiliations & Notes
  • F. A. Proudlock
    Ophthalmology, University of Leicester, Leicester, United Kingdom
  • R. J. McLean
    Ophthalmology, University of Leicester, Leicester, United Kingdom
  • S. Thomas
    Ophthalmology, University of Leicester, Leicester, United Kingdom
  • I. Gottlob
    Ophthalmology, University of Leicester, Leicester, United Kingdom
  • Footnotes
    Commercial Relationships F.A. Proudlock, None; R.J. McLean, None; S. Thomas, None; I. Gottlob, None.
  • Footnotes
    Support Nystagmus Network UK, University Hospitals of Leicester, Ulverscroft Foundation
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1104. doi:https://doi.org/
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    • Get Citation

      F. A. Proudlock, R. J. McLean, S. Thomas, I. Gottlob; The Effect of Memantine and Gabapentin on Changes in Nystagmus Waveform in Congenital Nystagmus. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1104. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To compare the changes in nystagmus waveform in a recently performed randomized double-masked placebo controlled study on the effects of gabapentin and memantine on patients with congenital nystagmus.

Methods:: Eye movements (250Hz) were recorded from 21 patients with congenital idiopathic nystagmus (CIN) and 27 patients who had congenital nystagmus associated with other ophthalmological conditions (secondary nystagmus, SN). They were compared prior to and following 8 weeks of memantine, gabapentin or placebo treatment. Nystagmus intensity and foveation (measured using the Extended Nystagmus Acuity Function, NAFX) were measured at positions from -24° to 24° eccentricity at 3° intervals along the axis of the nystagmus. Changes in intensity and NAFX before and after medication were estimated at the null point and from the mean of all positions. These were compared to measured changes in visual acuity.

Results:: Significant improvements in nystagmus intensity (F=7.7, p=0·001) and foveation (F=7.8, p=0·001) were evident at null point, with the nystagmus intensity showing improvements (F=4.7, p=0·02) for the mean of all positions from -24° to 24°. Patients with CIN showed similar improvements in nystagmus intensity and foveation as patients with SN, in contrast to visual acuity which improved much more in the CIN group compared to the SN group.

Conclusions:: Gabapentin and memantine reduce oscillations in both congenital idiopathic nystagmus and in congenital nystagmus associated with other ophthalmological conditions.

Clinical Trial:: MHRA CTA no. MF/8000/11727 MF/8000/11730

Keywords: eye movements • drug toxicity/drug effects • neuro-ophthalmology: cortical function/rehabilitation 
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