May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Dietary Antioxidants and Risk Factors for Age-Related Maculopathy
Author Affiliations & Notes
  • E. D. O'Connell
    Department of Ophthalmology, Mater Misercordia Hospital, Dublin 7, Ireland
  • S. Beatty
    Department of Ophthalmology, Waterford Regional Hospital, Waterford, Ireland
  • J. Stack
    Department of Physical and Quantitative Science,
    Waterford Institute of Technology, Waterford, Ireland
  • J. Nolan
    Department of Chemical and Life Science,
    Waterford Institute of Technology, Waterford, Ireland
  • Macular Pigment Research Group
    Department of Ophthalmology, Mater Misercordia Hospital, Dublin 7, Ireland
  • Footnotes
    Commercial Relationships E.D. O'Connell, None; S. Beatty, None; J. Stack, None; J. Nolan, None.
  • Footnotes
    Support Fighting Blindness
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1151. doi:https://doi.org/
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    • Get Citation

      E. D. O'Connell, S. Beatty, J. Stack, J. Nolan, Macular Pigment Research Group; Dietary Antioxidants and Risk Factors for Age-Related Maculopathy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1151. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: There is a growing body of evidence that oxidative stress is aetiologically important in the pathogenesis of age-related maculopathy (ARM), and that appropriate antioxidants of dietary origin may protect against this condition. Risk factors for ARM may be classed as established or putative, and we report a study designed to investigate whether such risk factors are associated with a dietary lack of antioxidants important for retinal health.

Methods:: Dietary, anthropometric and demographic details relating to 828 healthy Irish subjects, aged 20 to 60 years, were recorded in a cross-sectional fashion, and analysed for associations between risk factors for ARM and dietary intake of nutrients relevant to ocular health.

Results:: Of the established risk factors for ARM, increasing age was associated with a relative lack of dietary zeaxanthin (Z) (P<0.05) and tobacco use with a relative lack of dietary vitamin C (P<0.05). Of the putative risk factors for ARM, alcohol consumption was associated with a relative lack of dietary α-linoleic acid (ALA) (P<0.05), female gender with a relative lack of dietary zinc (P<0.05), hypercholesterolaemia (self-reported) with a relative lack of dietary vitamin A (P<0.01) and of dietary zinc (P<0.05) and blue irides with a relative lack of dietary lutein (L) (P<0.05).

Conclusions:: We have demonstrated that several variables related to risk for ARM are associated with a relative dietary lack of key nutrients. Our finding that age, the most important and universal risk factor for ARM, is associated with a relative lack of dietary Z, is an important finding which warrants further investigation.

Keywords: age-related macular degeneration • antioxidants • clinical (human) or epidemiologic studies: risk factor assessment 
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