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O. O. Maia Júnior, W. Y. Takahashi, M. T. Bonanomi, L. P. Cunha, T. Arantes, R. Barreto, J. Andrade Neto; Correlation of Clinical and Macular Structural Findings in Brazilian Patients With Stargardt’s Disease. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1190.
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To evaluate macular structural damage in Stargardt’s disease by optical coherence tomography, correlating with visual acuity and disease duration.
Patients with Stargardt’s disease were included and submitted to visual acuity (logMAR) measurement and a complete ophthalmologic examination. The complementary exams performed were color fundus photographs, fluorescein angiography and optical coherence tomography. All cases were re-examined for diagnostic confirmation and the duration of symptoms was determined. The control group was composed by the same number of subjects, matched by sex and age, without any ophthalmologic alteration or history of previous use of medications related to maculopathies.
The sample was composed by 22 (twenty two) patients with Stargardt’s disease, 11 (50%) male and 11 (50%) female. The duration of the disease varied from 3 to 21 years (mean of 11.4 ± 5.3 years, median of 11 years), 50% had initiated the symptoms in the first or second decade of live. The groups did not show significant statistical differences in age (p = 0.98) and sex. Concerning the macular thickness in optical coherence tomography, the variation in the study group was from 60 to 167 µm (mean of 103.3 ± 30.2 µm, median of 95.5 µm), differing significantly from the control group, that varied from 168 to 236 µm (mean of 204.8 ± 18.5 µm, median of 204 µm), presenting smaller values of thickness (p< 0.001). There was a negative and statistically significant correlation between the duration of disease and the macular thickness assessed by optical coherence tomography (r = -0.57 and p = 0.005). There was a positive correlation between the duration of the disease and the visual acuity (r = 0.50 and p = 0.0167) and a negative correlation between the visual acuity and the macular thickness in optical coherence tomography (r = -0.83 and p = 0.0001).
The results suggest that patients with Stargardt’s disease have a thinner macular thickness, when compared to normal subjects, and this reduction is related with the duration of symptoms of the disease. Additionally, the thickness and also the duration of the disease influence the visual prognosis of the patients.
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