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S. Makita, M. Miura, Y. Hong, M. Yamanari, T. Yatagai, Y. Yasuno; Doppler Optical Coherence Angiography for Retinal Vessels. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1197.
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© ARVO (1962-2015); The Authors (2016-present)
To observe the three-dimensional retinal vasculature and segment the retinal vessels with Doppler optical coherence angiography
Three-dimensional high-speed spectral domain OCT imaging is applied for the in vivo human eye. This system operates at 27,000 A-scan/s and acquires a three-dimensional volume set consisting of 1024 x 140 A-scans within 5.5 seconds. This volume set is processed by Doppler analysis for three-dimensional blood vessel imaging. For contrast enhancement and segmentation of the retinal vessels, two-dimensional line filtering based on the Hessian matrix is applied for en-face vessel images, and then, the line filter is applied for cross-sections of flow images, which is parallel to the blood vessels. Healthy normal volunteers are examined.
The contrast enhanced three-dimensional blood flow images reveal the retinal vessel structures. And the distribution of the retinal vessel angles is obtained by the line filtering
Doppler OCA enables the measurements of three-dimensional retinal vessel structure. The contrast enhancement and vessel angle measurement based on two-dimensional line filtering is rather realistic than three-dimensional filtering for large OCT volume set. The vessel angle measurement is one of the step toward absolute blood flow measurement.
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