May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Doppler Optical Coherence Angiography for Retinal Vessels
S. Makita; M. Miura; Y. Hong; M. Yamanari; T. Yatagai; Y. Yasuno
Author Affiliations & Notes
  • S. Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
  • M. Miura
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Department of Ophthalmology, Tokyo Medical University, Ami, Japan
  • Y. Hong
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
  • M. Yamanari
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
  • T. Yatagai
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
  • Y. Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships S. Makita, None; M. Miura, None; Y. Hong, None; M. Yamanari, None; T. Yatagai, None; Y. Yasuno, None.
  • Footnotes
    Support JST Grant, JSPS Grant 15760026, 18360029, 18•3827
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1197. doi:
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      S. Makita, M. Miura, Y. Hong, M. Yamanari, T. Yatagai, Y. Yasuno; Doppler Optical Coherence Angiography for Retinal Vessels. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1197.

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Abstract

Purpose:: To observe the three-dimensional retinal vasculature and segment the retinal vessels with Doppler optical coherence angiography

Methods:: Three-dimensional high-speed spectral domain OCT imaging is applied for the in vivo human eye. This system operates at 27,000 A-scan/s and acquires a three-dimensional volume set consisting of 1024 x 140 A-scans within 5.5 seconds. This volume set is processed by Doppler analysis for three-dimensional blood vessel imaging. For contrast enhancement and segmentation of the retinal vessels, two-dimensional line filtering based on the Hessian matrix is applied for en-face vessel images, and then, the line filter is applied for cross-sections of flow images, which is parallel to the blood vessels. Healthy normal volunteers are examined.

Results:: The contrast enhanced three-dimensional blood flow images reveal the retinal vessel structures. And the distribution of the retinal vessel angles is obtained by the line filtering

Conclusions:: Doppler OCA enables the measurements of three-dimensional retinal vessel structure. The contrast enhancement and vessel angle measurement based on two-dimensional line filtering is rather realistic than three-dimensional filtering for large OCT volume set. The vessel angle measurement is one of the step toward absolute blood flow measurement.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • image processing • retina 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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