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Y. Jiang, J. Hou, Y. Tao, K. Wang; Experimental Study in Fibrin Glue for Treating Choroidialysis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):713.
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The effectiveness and safety in the fibrin glue (fibrin tissueadhesive or fibrin glue, FG) treatment of choroidialysis.
72 New Zealand white rabbits were randomly divided into fivegroups, each left eye were injected 0.2 ml fibrin glue or N.S.They were subchoroidal glue Group, subchoroidal N.S. group,subretinal glue group, subretinal N.S. group and vitreous cavityglue group. The right eye was blank. These rabbits did indirectophthalmoscopy, fundus fluorescein angiography (FFA) and indocyaninegreen angiography (ICGA) and electroretinogram (ERG) and opticalmicroscopy before injection and 1 day, 3 days, 7 days, 14 days,30 days, 90 days after injection.
In group 1, 2 and 5 there was no significant difference in thelatency and amplitude pre-operation or post-operation (P>0.1), in group 3 and 4 amplitude of the ERG wave was lower thanpre-operation and the difference was significant (P <0.01and P <0.05); Optical microscope showed fibrin glue in rabbit’ssubchoroid caused acute inflammatory response in early stage,chronic inflammatory reaction with capillary proliferation andfibrous tissue proliferation in middle stage and remaining fibrosisin late stage, retinal structure had not changed significantly.
Fibrin glue facilitate the adhesion of choroid and sclera, therewas no significant impact on retinal morphology and function.
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