May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Interferon alpha 2a in the Treatment of Experimental Herpetic Keratitis
Author Affiliations & Notes
  • U. Erdem
    Ophthalmology, GATA Goz Klini I Etlik, Ankara, Turkey
  • F. C. Gundogan
    Ophthalmology, GATA Goz Klini I Etlik, Ankara, Turkey
  • A. Demirel
    Ophthalmology, GATA Goz Klini I Etlik, Ankara, Turkey
  • G. Sobaci
    Ophthalmology, GATA Goz Klini I Etlik, Ankara, Turkey
  • Footnotes
    Commercial Relationships U. Erdem, None; F.C. Gundogan, None; A. Demirel, None; G. Sobaci, None.
  • Footnotes
    Support Gulhane Military Medical Academy
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 730. doi:
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    • Get Citation

      U. Erdem, F. C. Gundogan, A. Demirel, G. Sobaci; Interferon alpha 2a in the Treatment of Experimental Herpetic Keratitis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):730.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To investigate the effect of interferon-alpha 2a in the treatment of experimental rabbit keratitis.

Methods:: Sixty rabbits were included. After a preliminary study with 20 rabbits for the feasibility of the experimental model, 32 albino New-Zealand rabbits were included. One cornea of each rabbit were inoculated subepithellially with 5-pfu Herper Simplex Virus Type 1 (HSV 1, Group 1). One corneas of eight rabbits were inoculated with balanced saline solution (Group 2). After 2 days in each group, 16 rabbits in the study group (Group 1a) were treated only with topical Trifluoridine solution (1%) and the remaining 16 rabbits (Group 1b) were treated with topical Trifluoridine solution (1%)+Interferon alpha-2a (30.000 IU/drop). Each solution was used as a drop with two hours interval between 08.00-20.00. The color photographs of the corneal lesions were evaluated planimetrically.

Results:: After 2 weeks’ treatment, corneal lesions in all rabbits in Group 1b improved when compared with pre-treatment lesions. In Group 1a, corneal lesions of 2 rabbits partially improved and keratouveitis secondary to endothelitis in a rabbit was detected The aquous PCR results revealed HSV 1 infection after 10 days in this rabbit. There was significant difference between Group 1a and Group 1b treatment results in planimetric analysis (p<0.01).

Conclusions:: Trifluoridine (1%)+Interferon alpha 2a treatment showed better results compared with trifluoridine treatment. This result showed topically administered interferon alpha 2a as a potentially terapotic agent in HSV 1 keratitis.

Clinical Trial:: gmma supported study

Keywords: antiviral drugs • herpes simplex virus • keratitis 
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