May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
PostAntibiotic Effect (PAE) of Fluoroquinolones Against Ocular Bacterial Pathogens
Author Affiliations & Notes
  • R. A. Eiferman
    University of Louisville, Louisville, Kentucky
    Ophthalmology,
  • J. W. Snyder
    University of Louisville, Louisville, Kentucky
    Microbiology,
  • J. Garr
    University of Louisville, Louisville, Kentucky
    Microbiology,
  • C. Johnson
    University of Louisville, Louisville, Kentucky
    Microbiology,
  • G. Munier
    University of Louisville, Louisville, Kentucky
    Microbiology,
  • Footnotes
    Commercial Relationships R.A. Eiferman, Alcon Laboratories, R; J.W. Snyder, None; J. Garr, None; C. Johnson, None; G. Munier, None.
  • Footnotes
    Support Alcon Laboratories
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 764. doi:
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    • Get Citation

      R. A. Eiferman, J. W. Snyder, J. Garr, C. Johnson, G. Munier; PostAntibiotic Effect (PAE) of Fluoroquinolones Against Ocular Bacterial Pathogens. Invest. Ophthalmol. Vis. Sci. 2007;48(13):764.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

The Post Antibiotic Effect (PAE) is the difference in time required by antibiotic exposed and unexposed cultures of the same organism to increase 1 log in CFU from baseline.This study determined the PAE of Ciprofoxacin, Levofloxacin, Moxifloxacin and Ofloxacin against susceptible strains of Staphyloccocus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa and Hemophilus influenzae

 
Methods:
 

MIC's and PAE's for each combination of fluoroquinolone and organism were determined by E-Test. 107 log phase bacteria at were exposed to the antibiotic for 1 hour and then inactivated and compared to a control culure. The average of triplicate trials in hours were calculated.

 
Results:
 

 

 
Conclusions:
 

All fluoroquinilones exhibited PAE. The PAE of Moxifloxacin against pseudomonas was greater than the other fluoroquinolones and was statistically significant.

 
Keywords: antibiotics/antifungals/antiparasitics • bacterial disease 
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