Purpose:
The Post Antibiotic Effect (PAE) is the difference in time required by antibiotic exposed and unexposed cultures of the same organism to increase 1 log in CFU from baseline.This study determined the PAE of Ciprofoxacin, Levofloxacin, Moxifloxacin and Ofloxacin against susceptible strains of Staphyloccocus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa and Hemophilus influenzae
Methods:
MIC's and PAE's for each combination of fluoroquinolone and organism were determined by E-Test. 107 log phase bacteria at were exposed to the antibiotic for 1 hour and then inactivated and compared to a control culure. The average of triplicate trials in hours were calculated.
Results:
Conclusions:
All fluoroquinilones exhibited PAE. The PAE of Moxifloxacin against pseudomonas was greater than the other fluoroquinolones and was statistically significant.
Keywords: antibiotics/antifungals/antiparasitics • bacterial disease