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R. A. Eiferman, J. W. Snyder, J. Garr, C. Johnson, G. Munier; PostAntibiotic Effect (PAE) of Fluoroquinolones Against Ocular Bacterial Pathogens. Invest. Ophthalmol. Vis. Sci. 2007;48(13):764.
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The Post Antibiotic Effect (PAE) is the difference in time required by antibiotic exposed and unexposed cultures of the same organism to increase 1 log in CFU from baseline.This study determined the PAE of Ciprofoxacin, Levofloxacin, Moxifloxacin and Ofloxacin against susceptible strains of Staphyloccocus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa and Hemophilus influenzae
MIC's and PAE's for each combination of fluoroquinolone and organism were determined by E-Test. 107 log phase bacteria at were exposed to the antibiotic for 1 hour and then inactivated and compared to a control culure. The average of triplicate trials in hours were calculated.
All fluoroquinilones exhibited PAE. The PAE of Moxifloxacin against pseudomonas was greater than the other fluoroquinolones and was statistically significant.
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