May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Eyelid Abcesses: Which Emperic Antibiotic?
Author Affiliations & Notes
  • K. Johnson
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • D. Miller
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • T. Johnson
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • Footnotes
    Commercial Relationships K. Johnson, None; D. Miller, None; T. Johnson, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 770. doi:
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      K. Johnson, D. Miller, T. Johnson; Eyelid Abcesses: Which Emperic Antibiotic?. Invest. Ophthalmol. Vis. Sci. 2007;48(13):770.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: Patients presenting with bacterial eyelid infections are treated empirically while waiting for culture and sensitivity results. The incidence of community-acquired methacillin-resistant Staphylococcus aureus has more than doubled since the 1980’s, raising the question of which medication should be used for this empiric treatment at first presentation.

Methods:: Microbiology specimens for eyelid cultures were reviewed from January 2000 through November 15, 2006 at the Bascom Palmer Eye Institute. The percent sensitivity of all organisms was evaluated for Ampicillin/Sulbactam, Cefazolin, Ciprofloxacin, Gentamicin, Trimethoprim/Sulfamethoxazole, and Vancomycin.

Results:: All gram positive isolates accounted for 74.5%, whereas gram negative organisms accounted for 25.5%. Staphylococcus aureus was the most common isolate (56.8%), with methacillin-resistance found in 35% of these cases. Against all isolates, the percent of organisms sensitive to the antibiotics were: Ampicillin/Sulbactam 57.9%, Cefazolin 58.5%, Ciprofloxacin 85.4%, Gentamicin 95.8%, Trimethoprim/Sulfamethoxazole 98.3%. Vancomycin was 99% sensitive for S. aureus and not measured for the gram negative organisms.

Conclusions:: With the rise in community-acquired MRSA, the efficacy of beta-lactam-based antibiotics is decreasing. Trimethoprim/Sulfamethoxazole shows high bacterial sensitivity with easy twice-daily dosing and should be considered in first-line empiric treatment of eyelid infections.

Keywords: antibiotics/antifungals/antiparasitics • eyelid • microbial pathogenesis: clinical studies 

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