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K. Kang, M. Kim; Efficacy of Topical Cyclosporine A in Cytokine Reduction After Alkali Burned Cornea. Invest. Ophthalmol. Vis. Sci. 2007;48(13):800.
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This study was conducted to investigate the effects of topical cyclosporine A(CsA) and prednisolone on inflammatory cytokine expression of the cornea after alkali injury.
Seven-week-old male ICR mice(n=66) were used in this study. To create alkali burns, 2ml of 0.5 N NaOH was applied to 108 corneas of mice. Injured mice corneas were divided into three groups : untreated(n=18), topical CsA administrated(n=18), topical prednisolone administrated (n=18) group. Interleukin-1α(IL-1α) and Interleukin-2(IL-2) concentrations of the injured corneas were quantitated using enzyme linked immunosorbent assay(ELISA) at 1,3 and 7 days after alkali injury.
Both CsA and prednisolone significantly suppressed the expression of IL-1α compaired to untreated group. Especially at day 3 and day 7 CsA significantly suppressed IL-1α compaired to prednisolone (P<0.05). CsA and prednisolone seemed to suppress the expression of IL-2 compaired to untreated group but there were no statistical significances between treated and untreated groups. Both agents significantly reduced corneal opacities.
Topical administration of prednisolone or CsA after alkali injury can be beneficial to prevention of early inflammation by suppressing inflammatory cytokine expression in the alkali burned cornea.
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