May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Ultrasound Biomicroscopy (UBM) of Zonular Anatomy in Unilateral Exfoliation Syndrome (XFS)
Z. Sbeity; S. Dorairaj; S. Reddy; C. Tello; J. M. Liebmann; R. Ritch
Author Affiliations & Notes
  • Z. Sbeity
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, New York
  • S. Dorairaj
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, New York
  • S. Reddy
    New York Medical College, Valhalla, New York
  • C. Tello
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, New York
  • J. M. Liebmann
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, New York
    Manhattan Eye and Ear and Throat Hospital, New York, New York
  • R. Ritch
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, New York
    New York Medical College, Valhalla, New York
  • Footnotes
    Commercial Relationships Z. Sbeity, None; S. Dorairaj, None; S. Reddy, None; C. Tello, None; J.M. Liebmann, None; R. Ritch, None.
  • Footnotes
    Support Supported in part by the Joseph Cohen Research fund of the New York Glaucoma Research Institute, New York, NY
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 808. doi:
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      Z. Sbeity, S. Dorairaj, S. Reddy, C. Tello, J. M. Liebmann, R. Ritch; Ultrasound Biomicroscopy (UBM) of Zonular Anatomy in Unilateral Exfoliation Syndrome (XFS). Invest. Ophthalmol. Vis. Sci. 2007;48(13):808.

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Abstract

Purpose:: To evaluate the ability of UBM to detect abnormalities in the zonular apparatus in unaffected eyes of patients with unilateral XFS using a standardized grading system.

Methods:: The affected and unaffected eyes of 17 patients with unilateral XFS (mean age, 67.9 ± 9.0 yrs) and 17 eyes of 17 control subjects (mean age 66.4 ± 12.0 yrs) underwent UBM. Radial sections detailing the lens and zonules at 12:00, 1:30, 3:00, 4:30, 6:00, 7:30, 9:00 and 10:30 clock hours were obtained. The images were graded by a masked, experienced UBM observer using the following standardized scoring system: 0) clear, well-defined zonules without patchy XFM deposits; 1) uneven and/or disrupted zonules without patchy deposits; 2) uneven and/or disrupted zonules with patchy deposits; 3) diffuse granulation of zonules and/or abnormal thick zonules and/or net or web-like structure between zonules; 4) total destruction of zonules. Affected meridians were compared by the Friedman test, while distributions of unaffected and affected eyes were compared using the Wilcoxon signed rank test.

Results:: In the control group, 15/17 eyes showed normal zonules; the remaining 2 eyes showed grade 1 changes in some meridians. The mean grade score was 0.04 ± 0.11 (SD) (median score, 0). Eyes with XFS had a higher score (p=0.008) than control eyes, with a mean score of 1.79 ± 0.89 (median 1.63; range, 0.63 - 4.0). In clinically unaffected, fellow eyes, the mean score was 1.32 ± 0.93, (median 1.13; range, 0.13 - 4.0) and was less than XFS eyes (p=0.003). 12 XFS eyes (70.6%) and 6 unaffected fellow eyes (35.3%) had grade 3 or 4 in at least one meridian (P= 0.07).

Conclusions:: Bilateral zonular involvement is present in subjects with clinically unilateral XFS. These zonular changes may be extensive in fellow eyes without clinically evident exfoliation material. UBM assessment of zonular status in fellow eyes prior to cataract extraction may aid in surgical planning.

Keywords: imaging/image analysis: clinical • ciliary body • degenerations/dystrophies 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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