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Y. Kondo, T. Miyake, T. Yamamoto; The Prevalence of Hypotony Maculopathy After Trabeculectomy With Adjunctive Mitomycin C. Invest. Ophthalmol. Vis. Sci. 2007;48(13):842.
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To assess the prevalence of hypotony maculopathy after trabeculectomy (TLE) with adjunctive mitomycin C (MMC).
The patients who underwent TLE with MMC in Gifu University hospital during September 1993 and December 2004 were reviewed retrospectively. The 0.04% MMC was administered for 5 minutes intraoperatively. All patients were followed up over 1 year. The prevalence was estimated and the risk factor of hypotony maculopathy was investigated using a discriminant analysis.
Six hundred thirty-five eyes were enrolled. Hypotony maculopathy developed in 43 eyes (6.8%). The prevalence of developmental glaucoma, primary open angle glaucoma, normal-tension glaucoma and primary angle-closure glaucoma were 16.4%, 7.0%, 4.0% and 5.7%, respectively. Age was significantly different between patients with hypotony maculopathy and ones without hypotony maculopathy (p<0.0001, Mann-Whitney U-test; 39.2±16.8 and 57.2±16.6 years old, respectively). Age, preoperative visual acuity and preop mean deviation were identified as risk factors for hypotony maculopathy after TLE with MMC. Duration of hypotony maculopathy affected the visual outcome. The duration of hypotony maculopathy is significantly different between the patients whose visual acuity decreased postoperatively over 4 lines and ones within 4 lines ( p<0.05, Mann-Whitney U-test; 358.7±406.0 and 130.9±185.0 days, respectively).
The prevalence of hypotony maculopathy after TLE with MMC was 6.8%. Younger patient with better visual acuity and better mean deviation has a higher risk to have hypotony maculopathy after TLE with MMC.
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