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M. Seong, J. Choi, S. Joe, C. Lee, M. S. Kook; C-reactive Protein and Lipid Profiles in Normal Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):849.
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To compare C-reactive protein (CRP) levels and lipid profiles between normal tension glaucoma (NTG) patients and healthy controls.
This study included 57 patients with NTG and 57 healthy control subjects. Each patient underwent Humphrey visual field examination and blood sampling for high-sensitive CRP (hsCRP) and lipid profile analysis. The patients were subsequently categorized into two groups based on their intraocular pressure (IOP) levels. Group A with IOP ≤ 14 mmHg consisted of 31 NTG subjects and 27 controls. Group B with IOP > 14 mmHg consisted of 26 NTG subjects and 30 controls. We compared hsCRP and lipid profiles between NTG patients and healthy controls in overall subjects and in each subgroups.
The overall NTG subjects showed significantly higher hsCRP values compared with healthy controls (P=0.005). Lipid profiles were not different between NTG subjects and controls. When the subjects were classified by IOP levels, NTG subjects had significantly higher hsCRP level than controls (P=0.001) for group A. In contrast, there was no difference in hsCRP level between NTG subjects and controls for group B (P=0.414). Lipid profiles were not different for both groups.
These findings suggest that higher CRP levels may be associated with NTG, especially in relatively low IOP level, and that dyslipidemia may not be associated with NTG.
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