May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The African Descent and Glaucoma Evaluation Study (ADAGES): Baseline Clinical and Visual Function Findings in Healthy Eyes
Author Affiliations & Notes
  • P. A. Sample
    University of California San Diego, La Jolla, California
    Department of Ophthalmology, Hamilton Glaucoma Center,
  • C. A. Girkin
    UAB Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
  • J. M. Liebmann
    New York Eye and Ear Infirmary, New York, New York
  • C. Boden
    University of California San Diego, La Jolla, California
    Department of Ophthalmology, Hamilton Glaucoma Center,
  • S. Jain
    University of California San Diego, La Jolla, California
    Biostatistics and Bioinformatics,
  • L. Becerra
    University of California San Diego, La Jolla, California
    Biostatistics and Bioinformatics,
  • F. A. Medeiros
    University of California San Diego, La Jolla, California
    Department of Ophthalmology, Hamilton Glaucoma Center,
  • C. Bowd
    University of California San Diego, La Jolla, California
    Department of Ophthalmology, Hamilton Glaucoma Center,
  • R. N. Weinreb
    University of California San Diego, La Jolla, California
    Department of Ophthalmology, Hamilton Glaucoma Center,
  • L. M. Zangwill
    University of California San Diego, La Jolla, California
    Department of Ophthalmology, Hamilton Glaucoma Center,
  • Footnotes
    Commercial Relationships P.A. Sample, Carl Zeiss Meditec, Haag-Streit, Welch-Allyn, F; C.A. Girkin, Carl Zeiss Meditec, Inc., F; J.M. Liebmann, Heidelberg Engineering, F; C. Boden, None; S. Jain, None; L. Becerra, None; F.A. Medeiros, Carl Zeiss Meditec, F; Heidelberg Engineering, Carl Zeiss Meditec, R; C. Bowd, None; R.N. Weinreb, Heidelberg Engineering, Carl Zeiss Meditec, F; Heidelberg Engineering, Carl Zeiss Meditec, R; L.M. Zangwill, Heidelberg Engineering, Carl Zeiss Meditec, F; Heidelberg Engineering, R.
  • Footnotes
    Support NEI EY14267 and NEI EY08208 (PAS), NEI EY11008 (LMZ), NEI EY13959 and Eyesight Foundation (CAG), Grant for subject's glaucoma medications (Alcon Laboratories Inc., Allergan, Pfizer Inc., SANTEN Inc.)
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 856. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P. A. Sample, C. A. Girkin, J. M. Liebmann, C. Boden, S. Jain, L. Becerra, F. A. Medeiros, C. Bowd, R. N. Weinreb, L. M. Zangwill; The African Descent and Glaucoma Evaluation Study (ADAGES): Baseline Clinical and Visual Function Findings in Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2007;48(13):856.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To compare baseline clinical and visual field (VF) findings between healthy participants of African Descent (AD; n=217) with those of European Descent (ED; n=209).

 
Methods:
 

ADAGES is a prospective, longitudinal, multi-center observational cohort study of healthy, ocular hypertensive, suspect, and glaucoma participants (n=1,224). 852 eyes from 426 participants (362 from ADAGES and 64 from the Diagnostic Innovations in Glaucoma Study (DIGS) were included if they had normal fundus exams, IOP <22 mm Hg, and no evidence of glaucoma on masked review of stereophotographs. VF results were not used to classify eyes. Results from short-wavelength automated perimetry (SWAP), frequency-doubling technology perimetry (FDT), and standard automated perimetry (SAP), along with clinical measurements and risk factors were obtained. Categorical variables were compared using Fisher's exact test and continuous variables with the t-test.

 
Results:
 

There were no significant differences between groups in age, gender, presence of heart disease, family history, or IOP. A significantly (p< .004) higher proportion of AD had diabetes (pre-retinopathy) or systemic hypertension (p=0.003) than ED subjects, 6% AD vs.10% ED and 28% AD vs. 16% ED, respectively. Cup/disc ratio was significantly larger and CCT was significantly thinner for AD than ED. AD showed significantly worse MD and PSD VF indices than ED.

 
Conclusions:
 

Significant differences on all VF tests and a number of clinical findings between healthy eyes from persons of AD compared with those of ED may be important to take into account when interpreting results from patient eyes. These differences may be signs of early eye disease or true differences between the healthy groups. ADAGES and DIGS will be important for discriminating these two possibilities.  

 
Keywords: visual fields • perimetry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×