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P. A. Sample, C. A. Girkin, J. M. Liebmann, C. Boden, S. Jain, L. Becerra, F. A. Medeiros, C. Bowd, R. N. Weinreb, L. M. Zangwill; The African Descent and Glaucoma Evaluation Study (ADAGES): Baseline Clinical and Visual Function Findings in Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2007;48(13):856.
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To compare baseline clinical and visual field (VF) findings between healthy participants of African Descent (AD; n=217) with those of European Descent (ED; n=209).
ADAGES is a prospective, longitudinal, multi-center observational cohort study of healthy, ocular hypertensive, suspect, and glaucoma participants (n=1,224). 852 eyes from 426 participants (362 from ADAGES and 64 from the Diagnostic Innovations in Glaucoma Study (DIGS) were included if they had normal fundus exams, IOP <22 mm Hg, and no evidence of glaucoma on masked review of stereophotographs. VF results were not used to classify eyes. Results from short-wavelength automated perimetry (SWAP), frequency-doubling technology perimetry (FDT), and standard automated perimetry (SAP), along with clinical measurements and risk factors were obtained. Categorical variables were compared using Fisher's exact test and continuous variables with the t-test.
There were no significant differences between groups in age, gender, presence of heart disease, family history, or IOP. A significantly (p< .004) higher proportion of AD had diabetes (pre-retinopathy) or systemic hypertension (p=0.003) than ED subjects, 6% AD vs.10% ED and 28% AD vs. 16% ED, respectively. Cup/disc ratio was significantly larger and CCT was significantly thinner for AD than ED. AD showed significantly worse MD and PSD VF indices than ED.
Significant differences on all VF tests and a number of clinical findings between healthy eyes from persons of AD compared with those of ED may be important to take into account when interpreting results from patient eyes. These differences may be signs of early eye disease or true differences between the healthy groups. ADAGES and DIGS will be important for discriminating these two possibilities.
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