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G. Rebolleda, S. Noval, F. J. Muñoz-Negrete, F. Arnalich-Montiel, J. L. Garcia-Perez; Pathologic Optic-Disc Cupping After Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):915.
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To determine with Optic Coherence Tomography (OCT) if cup-to-disc ratio modifies after a monosymptomatic optic neuritis.
Fifty-eyes (50 patients) suffering a monocular acute optic neuritis were included and followed for at least one year. Estimation of Cup/Disk Area Ratio (CDAR) and Cup/Disk Vertical Ratio (CDVR) were made with OCT scanning (Fast optic disc strategy).
One year after the optic neuritis episode, the mean overall CDAR and CDVR were significantly higher in the affected eye compared with normal eye (0.5 ± 0.14 vs 0.39 ± 0.11 and 0.41 ± 0.18 vs 0.29 ± 1.6; P = 0.000 respectively). A CDAR and CDVR difference ≥ 0.2 was found in 13% and 23.2% of the eyes respectively. A statistically significant correlation was found between CDAR and CDVR difference with the average RNFL thickness (r = -0.688 and -0,551 respectively; P = 0.000). Correlations were also significant between CDAR and CDVR difference and the visual acuity in the affected eye at one year of follow-up (r = -0.651,-0.488 respectively; P = 0.000).
Optic neuritis should be included in the list of entities causing pathological optic nerve cupping. Patient history, visual fields assessment and funduscopic findings are the key to unlocking the diagnosis of glaucomatous versus nonglaucomatous optic-disc cupping.
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