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A. K. Shah, D. MacKenzie, M. Kahook, A. Ciardella, N. Faberowski; A Comparison of Central Corneal Thickness Measurements Obtained by Inspection and Pachymetry. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1260. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the estimated central corneal thickness (CCT) determined by inspection with the slit lamp by two independent examiners (resident physician [Examiner A] and attending physician [Examiner B]) to the actual measurement obtained by ultrasound (pachymetry).
Thirty eyes of 15 glaucoma suspect patients were enrolled in this prospective pilot study. CCT was estimated by inspection by 2 examiners independent of each other, and values were recorded numerically in microns. A measurement of CCT was then performed with ultrasound pachymetry by both examiners independently. The estimated measurements of each examiner were compared to the ultrasound measurements and to each other.
Mean age of the patients was 48.6 +/- 20.8 years, and average corneal thickness by pachymetry in the study population was 537.8 +/- 48.0 microns (range 436-599 microns). There was no statistical difference between pachymetry measurements obtained by the two examiners. The mean difference between the estimated and measured CCT was 26.0 +/- 17.8 and 25.5 +/- 14.0 microns for Examiners A and B, respectively. The paired student's t-test was used to compare the measurements obtained by inspection with the objective values obtained by pachymetry for each of the two examiners, and this analysis did not reveal any statistically significant differences (p=0.52 and 0.97 for Examiners A and B, respectively). Furthermore, there was very minimal interexaminer variation of CCT estimates.
CCT has been shown to be an important clinical factor in determining risk level for future glaucoma development in some glaucoma suspect patients. Careful inspection of the cornea can accurately estimate the central corneal thickness as obtained by pachymetry and should be incorporated into the routine ocular examination.
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