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Y. Nomura, S. Ataka, S. Nakakura, K. Kurita, K. Shiraki; Effects of Trabeculectomy With Mitomycin C on 24-Hour Intraocular Pressure of Contralateral Eyes. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1263.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the effects of trabeculectomy with mitomycin C (MMC) on the intraocular pressure (IOP) of contralateral eyes.
Among the patients who had surgery from 2005 till 2006, unilaterally-treated eight patients (5 males and 3 females) who had successful course with post-operative IOP at office (office IOP) (<13mmHg) and whose pre- and post- operative 24-hour IOP could be measured were reviewed retrospectively. The mean patient age was 61.5 years old (range, 21-82 years old). Three patients had normal tension glaucoma, and five patients had primary open angle glaucoma. The pre-operative medication of anti-glaucomatous drugs on the contralateral eyes was continued in all patients. The pre- and 6 months post-operative mean office IOPs were both the average of the IOPs on three consecutive visits. The 24-hour IOPs were measured with a Goldmann applanation tonometer at 3-hour intervals in the sitting position preoperatively and 6 months after the surgery.
In the operated eyes, the mean office IOP, the mean 24-hour IOP, and the 24-hour IOP fluctuation decreased significantly from 16.75 ± 6.45 mmHg to 10.13 ± 2.85 mmHg (p<0.05), from 18.86 ± 5.35 mmHg to 9.67 ± 2.38 mmHg (p<0.01), from 9.50 ± 3.25 to 3.25 ± 1.58 mmHg (p<0.01), respectively. In the contralateral eyes, the mean office IOP and the mean 24-hour IOP showed no statistically significant differences with 15.63 ± 3.66 mmHg preoperatively and 14.63±3.11 postoperatively (p=0.57), and similarly 16.71 ± 3.23 mmHg and 15.43 ± 3.23 mmHg (p=0.44), respectively. However, the 24-hour IOP fluctuation decreased significantly from 9.00 ± 3.25 mmHg to 5.00 ± 1.51 (p <0.01).
Trabeculectomy with MMC may reduce the diurnal fluctuation of IOP in contralateral eyes.
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