May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Corneal Endothelial Cell Density in Open Angle Glaucoma
Author Affiliations & Notes
  • S. A. Gandolfi
    Ophthalmology, University of Parma, Parma, Italy
  • G. Bacchi
    Ophthalmology, University of Parma, Parma, Italy
  • G. Ferrari
    Ophthalmology, University of Parma, Parma, Italy
  • C. Sangermani
    Ophthalmology, University of Parma, Parma, Italy
  • M. Tardini
    Ophthalmology, University of Parma, Parma, Italy
  • N. Ungaro
    Ophthalmology, University of Parma, Parma, Italy
  • Footnotes
    Commercial Relationships S.A. Gandolfi, None; G. Bacchi, None; G. Ferrari, None; C. Sangermani, None; M. Tardini, None; N. Ungaro, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1282. doi:
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    • Get Citation

      S. A. Gandolfi, G. Bacchi, G. Ferrari, C. Sangermani, M. Tardini, N. Ungaro; Corneal Endothelial Cell Density in Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1282.

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      © ARVO (1962-2015); The Authors (2016-present)

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To measure the cell density of the corneal endothelium in glaucomatouseyes (a) at diagnosis and (b) after longterm medical therapy


A first cohort of 126 consecutive eyes , scheduled for cataractsurgery and urrently treated with multidose topical hypotensivedrugs , were selected for the study and matched by age withcontrol eyes. A second cohort of 56 untreated newly diagnosedglaucomatous eyes was matche dby age with 56 control eyes referringto the outpatient clinic for near refraction assessment. exclusioncfrieria : previous bulbar surgery or laser , diabetes, historyof keratitis, chronic artificial tears, bulbar trauma, uveitis,narrow angle , PEX Endothelial cell count was performed witha non-contact Topcon SP2000 P endotthelial specular microscope.Eyes were divided into the following categories: (a) < 1000cells, (b) 1000-1500, (c) 1500-2000, (d) 2000-2500, (e) >2500 cells.


The data from the treated patients are summarized in the followingtable (chi square = 113,p < 0.00001). The cell density was inversely related to theduration of treatment (Spearman rank regression analysis, p< 0.001). No correlation was detected betwwen cell densityand (a) number of scheduled eyedrops / day (Spearman rank regressionanalysis, p = 0.345) and (b) mean IOP of the daily phasing duringtreatment (Spearman rank regression analysis, p = 0.127) Thedata from the untreated patients are as follows: (chi square test, p = 0.179) The cell densitymoderately correlated with the mean IOP of the daily phasing(Spearman rank regression analysis, p = 0.045). 



Corneal endothelial cell density is lower in open angle glaucomatouseyes undergoing longterm multidose medical treatment

Keywords: cornea: endothelium • intraocular pressure • drug toxicity/drug effects 

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