May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Duplex Vision in Mice
Author Affiliations & Notes
  • Y. Umino
    Ophthalmology, SUNY Upstate Medical Univ, Syracuse, New York
  • E. Solessio
    Ophthalmology, SUNY Upstate Medical Univ, Syracuse, New York
  • R. Hafler
    Ophthalmology, SUNY Upstate Medical Univ, Syracuse, New York
  • R. Barlow
    Ophthalmology, SUNY Upstate Medical Univ, Syracuse, New York
  • Footnotes
    Commercial Relationships Y. Umino, None; E. Solessio, None; R. Hafler, None; R. Barlow, None.
  • Footnotes
    Support NIH Grant EY00667, Lions Club of Central New York and Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1289. doi:https://doi.org/
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    • Get Citation

      Y. Umino, E. Solessio, R. Hafler, R. Barlow; Duplex Vision in Mice. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1289. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Assess scotopic and photopic vision in mice with behavioral techniques.

Methods:: We tested visual sensitivity of wildtype (C57BL/6J), rod-less (Gnat2cpfl3) and cone-less (rod transducin α KO) mice by observing their optomotor responses to rotating sinusoidal patterns (Optomotry©) with a double-blind procedure. We measured the spatial and temporal contrast functions over a wide range of illumination (5.6x10-7 cd/m2 to 70 cd/m2).

Results:: Mice can see over a 100 million-fold range of illumination using both rods and cones. Rods mediate vision under dim illuminations (< 3x10-4 cd/m2) whereas cones mediate vision with bright level (> 3x10-4 cd/m2). At photopic light levels the contrast sensitivity functions were broadly tuned (0.031 to 0.511 cyc/deg) and band-pass in shape. The contrast sensitivity was nearly invariant over a 30000-fold increase in intensity consistent with Weber’s law. For all spatial frequencies, sensitivity was tuned to the speed of rotation (peak: ~12 deg/sec). Rod-less and wildtype mice had similar sensitivities in the photopic range whereas cone-less mice were completely insensitive. At scotopic light levels, the spatial contrast sensitivity was low-pass in shape, and the spatial frequency range was limited to approximately 0.1-0.2 cyc/deg. Cone-less and wildtype mice had similar sensitivities in the scotopic range, but rod-less mice were insensitive. Remarkably, in the scotopic range visual sensitivity is tuned to the temporal frequency of the rotating pattern rather than to its speed of rotation.

Conclusions:: Mice process visual information differently under photopic and scotopic conditions.NIH Grant EY00667, Lions Club of Central New York and Research to Prevent Blindness

Keywords: photoreceptors • retinal degenerations: cell biology 
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