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F. C. Gundogan, U. Erdem, G. Sobaci, S. Memisoglu, Y. Uysal, A. Bayer; The Effect of Etanercept on Rabbit Electroretinogram. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1290. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the effect of etanercept, a potentially therapoetic agent for inflammatory eye diseases, on full-field rabbit electroretinogram (ERG).
One eye of 5 rabbits were given 250 microgram and one eye of 5 rabbits were given 500 microgram etarnecept in 0.1 ml solution intravitreally. Balanced saline solution was injected to the fellow eyes. DTL fiber electrodes were used for active electrodes. ERGs were recorded with Roland-Consult RetiPORT system (Wiesbaden-Germany) before injections (BI), 3 days (3D) , 2 weeks (2W) and 4 weeks (4W) after the injections. The significances were investigated between the pre-injection (BI) and post-injection (3D, 2W, 4W) comparisons.
Neither scotopic nor photopic ERG components revealed retinal toxicity. There was no sigificant difference between the a- and b- wave amplitudes and implicite times between pre-injection and post-injection comparisons (BI-3D, BI-2W, BI-4W, p>0.05). There was also no significant difference for oscillatory potential parameters.
In accordance with the published studies in the literature, this electrophysiological study shows the safety of intravitreally administered etanercept on retinal function.
GMMA supported study
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