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E. Cerman, O. Yenice, H. Kazokoglu; Vitreous and Serum Levels of Leptin and VEGF in Diabetic Patients. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1407. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the role of leptin and VEGF in the pathogenesis of diabetic retinopathy by detecting simultaneous serum and vitreous levels.
Serum and vitreous levels of leptin and VEGF were detected synchronously in the vitreous and serum samples of 15 patients classified by the presence and type of diabetic retinopathy (proliferatif versus nonproliferative diabetic retinopathy) and 6 patients without diabetic retinopathy who served as controls. Parameters (sex, age, body mass index, blood glucose levels, glycosylated hemoglobin, lipid profile) which might affect serum or vitreous levels of leptin and VEGF were also studied.
Serum and vitreous levels VEGF and leptin of control patients and cases with proliferative (PDR) and nonproliferative (NPDR) diabetic retinopathy are shown in Table 1. Vitreous VEGF were significantly higher (p=0.005) in cases with diabetic retinopathy and the others were not significant (p>0.05). A significant correlation was detected between serum glycosylated hemoglobin levels and vitreous levels of VEGF (r=0, 59 p=0,005. The difference between cases with and without diabetic retinopathy and within subgroups of diabetics was not significant (p>0.05). Vitreous leptin levels correlated with serum leptin levels (r=0,63, p=0,002). Serum levels of leptin were significantly higher in females (35,05±9,34 ng/ml ) than in males (25,89±3,50 ng/ml ) and correlated with body mass index (r=0,862,p<0,001). A positive correlation between vitreous levels of VEGF and vitreous/serum ratio of leptin levels was also detected (r=0,48, p=0,026).
Vitreous levels of VEGF were found to be higher in cases with diabetic retinopathy. Vitreous levels of leptin mainly reflect serum levels of leptin. As the rise in vitreus VEGF level was accompanied wit increasing levels of vitreous/serum leptin, it was considered that elevated levels of vitreous VEGF could cause disruption of blood retina barrier and augment diffusion of leptin from serum to vitreous. Table 1.
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