May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Cardiovascular Disease and Hypertension Are Strong Risk Factors for Choroidal Neovascularisation
Author Affiliations & Notes
  • U. Chakravarthy
    Queens University of Belfast, Belfast, United Kingdom
    Ophthalmology,
    Ophthalmology, The Queen's University of Belfast, Belfast, United Kingdom
  • R. E. Hogg
    Queens University of Belfast, Belfast, United Kingdom
    Ophthalmology,
  • J. V. Woodside
    Queens University of Belfast, Belfast, United Kingdom
    Nutrition,
  • A. E. Fletcher
    Epidemiology and Aging, The London School of Hygiene, London, United Kingdom
  • W. Chan
    Ophthalmology, The Royal Victoria Hospital, Belfast, United Kingdom
  • A. Knox
    Ophthalmology, The Royal Victoria Hospital, Belfast, United Kingdom
  • Footnotes
    Commercial Relationships U. Chakravarthy, None; R.E. Hogg, None; J.V. Woodside, None; A.E. Fletcher, None; W. Chan, None; A. Knox, None.
  • Footnotes
    Support European VI th Framework
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1442. doi:https://doi.org/
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    • Get Citation

      U. Chakravarthy, R. E. Hogg, J. V. Woodside, A. E. Fletcher, W. Chan, A. Knox; Cardiovascular Disease and Hypertension Are Strong Risk Factors for Choroidal Neovascularisation. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1442. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: .To investigate the association of cardiovascular risk factors and inflammatory markers with neovascular age-related macular degeneration (AMD)

Methods:: Cases (195) with neovascular AMD in at least one eye were recruited from hospital eye clinics . Other participants (n = 205 people) aged 65 years and over were recruited through a population based survey . Clinic and community participants underwent a detailed ophthalmic examination with fundus imaging, were interviewed for assessment of risk factors and provided a blood sample. All participants were classified by fundus image grading on the basis of the eye with more severe AMD features.

Results:: There were 195 participants with choroidal neovascularisation in at least one eye, 97 non neovascular AMD and 115 controls (no drusen or pigmentary irregularities in either eye). In confounder adjusted logistic regression, a history of cardiovascular disease was strongly associated with neovascular AMD (OR 7.53 (CI 2.78-20.41)). Cigarette smoking (OR 3.71, CI 1.25-11.06), being in the highest quartile of BMI (OR 3.82 , CI 1.22-12.01), grade 2 hypertension (OR 3.21 CI 1.14-8.98), and being in the highest quartile of serum cholesterol (4.66 CI 1.35-16.13) were positively associated with neovascular AMD. There was no association between AMD status and serum VCAM or ICAM.

Conclusions:: Our results strongly suggest that cardiovascular disease is an etiological factor in the development of choroidal neovascularisation in a proportion of older adults and highlight the importance of control of blood pressure and cholesterol, avoidance of smoking and maintenance of a normal body weight

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • age-related macular degeneration • choroid: neovascularization 
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