May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Intravitreal Bevacizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome
Author Affiliations & Notes
  • R. Schadlu
    Ophthalmology & Visual Sciences, Washington University School of Medicine, Saint Louis, Missouri
    Barnes Retina Institute, Saint Louis, Missouri
  • A. Sheybana
    Ophthalmology & Visual Sciences, Washington University School of Medicine, Saint Louis, Missouri
  • G. K. Shah
    Barnes Retina Institute, Saint Louis, Missouri
  • K. J. Blinder
    Barnes Retina Institute, Saint Louis, Missouri
  • Footnotes
    Commercial Relationships R. Schadlu, None; A. Sheybana, None; G.K. Shah, None; K.J. Blinder, None.
  • Footnotes
    Support Washington University School of Medicine, Department of Ophthalmology and Visual Sciences, Retina Research and Development Foundation, Barnes Retina Institute
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1458. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R. Schadlu, A. Sheybana, G. K. Shah, K. J. Blinder; Intravitreal Bevacizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1458. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To define the role of intravitreal bevacizumab in individuals with choroidal neovascularization (CNV) due to ocular histoplasmosis syndrome (OHS).

Methods:: 28 eyes of 28 patients with OHS complicated by CNV underwent intravitreal injection of 1.25 mg bevacizumab. Some patients had previously failed photodynamic therapy. Data was accrued via retrospective chart review.

Results:: The average pre-treatment LogMAR visual acuity was 0.65 (Snellen equivalent of 20/88). Ongoing mean follow-up was 22.4 weeks and on average, treatment amounted to 1.8 intravitreal injections. Average final LogMAR visual acuity was 0.43 (Snellen equivalent of 20/54). 4 eyes (14%) experienced decreased central acuity at the end of the observation period (mean decrease of 0.37 LogMAR units [standard error of the mean (SEM) = 0.18]). 4 eyes (14%) maintained their visual acuity. The remaining 20 eyes (71%) experienced an increase in central visual acuity (mean improvement of 0.38 LogMAR units [SEM = 0.06]).

Conclusions:: Intravitreal bevacizumab may improve or stabilize visual acuity in a significant majority of patients with neovascular complications of OHS (85% in our our study population). Further studies are needed to help delineate criteria for patient selection and to corroborate our findings.

Keywords: choroid: neovascularization • chorioretinitis • injection 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×