Abstract
Purpose::
To examine the role of TIMP-3 in the development of thechoroid vasculature.
Methods::
TIMP-3 deficient mice were utilized for the study. India inkvascular perfusion followed by whole-mount choroidpreparations were utilized to visualize vascular morphology. In addition, in situ zymography was performed to assess gelatinase activity.
Results::
An abnormal choroid vasculature in conjunction with increased gelatinase activity was observed in TIMP-3 deficient mice when compared with WT littermates.
Conclusions::
TIMP-3 plays an important role in the development of the choroid vasculature.
Keywords: choroid • development • choroid: neovascularization