May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Regulation of Choroidal Vasculature by Tissue Inhibitor of Metalloproteinase-3 (TIMP-3).
Author Affiliations & Notes
  • Q. Ebrahem
    Ophthalmic Research-ColeEye Inst, Cleveland Clinic Foundation, Cleveland, Ohio
  • B. Anand-Apte
    Ophthalmic Research-ColeEye Inst, Cleveland Clinic Foundation, Cleveland, Ohio
  • Footnotes
    Commercial Relationships Q. Ebrahem, None; B. Anand-Apte, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1463. doi:https://doi.org/
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    • Get Citation

      Q. Ebrahem, B. Anand-Apte; Regulation of Choroidal Vasculature by Tissue Inhibitor of Metalloproteinase-3 (TIMP-3).. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1463. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To examine the role of TIMP-3 in the development of thechoroid vasculature.

Methods:: TIMP-3 deficient mice were utilized for the study. India inkvascular perfusion followed by whole-mount choroidpreparations were utilized to visualize vascular morphology. In addition, in situ zymography was performed to assess gelatinase activity.

Results:: An abnormal choroid vasculature in conjunction with increased gelatinase activity was observed in TIMP-3 deficient mice when compared with WT littermates.

Conclusions:: TIMP-3 plays an important role in the development of the choroid vasculature.

Keywords: choroid • development • choroid: neovascularization 
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