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Q. Ebrahem, B. Anand-Apte; Regulation of Choroidal Vasculature by Tissue Inhibitor of Metalloproteinase-3 (TIMP-3).. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1463.
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To examine the role of TIMP-3 in the development of thechoroid vasculature.
TIMP-3 deficient mice were utilized for the study. India inkvascular perfusion followed by whole-mount choroidpreparations were utilized to visualize vascular morphology. In addition, in situ zymography was performed to assess gelatinase activity.
An abnormal choroid vasculature in conjunction with increased gelatinase activity was observed in TIMP-3 deficient mice when compared with WT littermates.
TIMP-3 plays an important role in the development of the choroid vasculature.
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