May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Lutein Inhibits Choroidal Neovascularization in Mice
Author Affiliations & Notes
  • K. Izumi
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
  • N. Nagai
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
  • S. Satofuka
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
  • T. Koto
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
  • H. Mochimaru
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
  • K. Tsubota
    Keio University School of Medicine, Tokyo, Japan
    Department of Ophthalmology,
  • K. Ohgami
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • S. Ohno
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • S. Ishida
    Keio University School of Medicine, Tokyo, Japan
    Laboratory of Retinal Cell Biology,
    Department of Ophthalmology,
  • Footnotes
    Commercial Relationships K. Izumi, Eye Ambitious, Co Ltd, F; N. Nagai, None; S. Satofuka, None; T. Koto, None; H. Mochimaru, None; K. Tsubota, None; K. Ohgami, Eye Ambitious, Co Ltd, F; S. Ohno, Eye Ambitious, Co Ltd, F; S. Ishida, Eye Ambitious, Co Ltd, F.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1468. doi:https://doi.org/
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    • Get Citation

      K. Izumi, N. Nagai, S. Satofuka, T. Koto, H. Mochimaru, K. Tsubota, K. Ohgami, S. Ohno, S. Ishida; Lutein Inhibits Choroidal Neovascularization in Mice. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1468. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Lutein deposits in the macula of human eyes with high concentration and is well known as an eye-protective nutrient for its beneficial effects on eye diseases such as age-related macular degeneration. The purpose of the current study is to investigate the effect of lutein on the development of experimental choroidal neovascularization (CNV) with underlying molecular mechanisms.

Methods:: Laser photocoagulation was used to induce CNV in C57BL/6J mice. Lutein (10 or 100mg/kg BW) was administered immediately after photocoagulation. One week after photocoagulation, CNV volume was evaluated by volumetric measurements. The mRNA and protein levels of ICAM-1 in the retinal pigment epithelium (RPE)-choroid complex were examined by RT-PCR and ELISA, respectively.

Results:: CNV volume was significantly (P < 0.05) suppressed by the treatment with lutein (328,192 +133,693 µm3 for 100mg/kg BW, 331,702 +187,414 µm3 for 10mg/kg BW), compared with vehicle-treated animals (459,099+189,514 µm3). ICAM-1 levels, elevated by CNV induction, were also significantly (P < 0.05) suppressed by lutein administration.

Conclusions:: Lutein treatment led to significant suppression of CNV development together with inflammatory processes including ICAM-1 upregulation in the RPE-choroid complex.

Keywords: age-related macular degeneration • choroid: neovascularization • nutritional factors 
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