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K. Izumi, N. Nagai, S. Satofuka, T. Koto, H. Mochimaru, K. Tsubota, K. Ohgami, S. Ohno, S. Ishida; Lutein Inhibits Choroidal Neovascularization in Mice. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1468.
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© ARVO (1962-2015); The Authors (2016-present)
Lutein deposits in the macula of human eyes with high concentration and is well known as an eye-protective nutrient for its beneficial effects on eye diseases such as age-related macular degeneration. The purpose of the current study is to investigate the effect of lutein on the development of experimental choroidal neovascularization (CNV) with underlying molecular mechanisms.
Laser photocoagulation was used to induce CNV in C57BL/6J mice. Lutein (10 or 100mg/kg BW) was administered immediately after photocoagulation. One week after photocoagulation, CNV volume was evaluated by volumetric measurements. The mRNA and protein levels of ICAM-1 in the retinal pigment epithelium (RPE)-choroid complex were examined by RT-PCR and ELISA, respectively.
CNV volume was significantly (P < 0.05) suppressed by the treatment with lutein (328,192 +133,693 µm3 for 100mg/kg BW, 331,702 +187,414 µm3 for 10mg/kg BW), compared with vehicle-treated animals (459,099+189,514 µm3). ICAM-1 levels, elevated by CNV induction, were also significantly (P < 0.05) suppressed by lutein administration.
Lutein treatment led to significant suppression of CNV development together with inflammatory processes including ICAM-1 upregulation in the RPE-choroid complex.
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