May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Expression of Hepatocyte Growth Factor and Its Receptor c-Met in Retinoblastoma
Author Affiliations & Notes
  • P. V. Acharya
    Wright State University School of Medicine, Dayton, Ohio
  • M. Kandalam
    Department of Ocular Pathology, Sankara Nethralaya, Chennai, India
  • J. Biswas
    Department of Ocular Pathology, Sankara Nethralaya, Chennai, India
  • S. Krishnakumar
    Department of Ocular Pathology, Sankara Nethralaya, Chennai, India
  • Footnotes
    Commercial Relationships P.V. Acharya, None; M. Kandalam, None; J. Biswas, None; S. Krishnakumar, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1595. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P. V. Acharya, M. Kandalam, J. Biswas, S. Krishnakumar; Expression of Hepatocyte Growth Factor and Its Receptor c-Met in Retinoblastoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1595. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: Hepatocyte growth factor/scatter factor (HGF) and its receptor, c-Met, have been identified in a variety of normal and neoplastic tissue types, implicating these factors in tissue regeneration and tumor progression. We investigated the expression and distribution of HGF and c-Met in retinoblastoma (RB) to evaluate the possible influence of HGF and c-Met on retinoblastoma invasiveness.

Methods:: Thirty archival RB specimens were divided in to 2 groups. Group A (n = 16) comprised of tumor samples with no invasion and Group B (n = 14) comprised of tumors with invasion of the choroid (focal, diffuse), optic nerve (laminar, post-laminar, surgical end), and orbit. Sections were immunostained with monoclonal antibodies to HGF and polyclonal antibody to c-Met and immunoreactivity was assessed.

Results:: In Group A (non-invasive) tumors, HGF was expressed in 75% (12/16) and c-Met was expressed in 81% (13/16) of the tumor specimens. In Group B (invasive) tumors, HGF was expressed in 100% (14/14) and c-Met was expressed in 100% (14/14) of the tumor specimens. The expression of HGF (p = 0.010) and c-Met (p = 0.002) were higher in invasive tumors compared to non-invasive tumors.

Conclusions:: Increased expression of HGF and c-Met were observed in invasive RB. Further studies will help clarify the role of HGF and c-Met in retinoblastoma and identify targets for early screening and anticancer drug development.

Keywords: tumors • retinoblastoma • immunohistochemistry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×