May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Antiangiogenic Activity in Human Tear Fluid
Author Affiliations & Notes
  • O. Abdiu
    Dept of Ophthalmology, Karolinska Inst/St Eriks Eye Hosp, Stockholm, Sweden
  • G. Van Setten
    Dept of Ophthalmology, Karolinska Inst/St Eriks Eye Hosp, Stockholm, Sweden
  • Footnotes
    Commercial Relationships O. Abdiu, None; G. Van Setten, None.
  • Footnotes
    Support Synfrämjandets Forskningsfond, Stockholm, Sweden
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1693. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      O. Abdiu, G. Van Setten; Antiangiogenic Activity in Human Tear Fluid. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1693. doi:

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose:: Pigment-epithelium-derived-factor (PEDF) is a known inhibitor of angiogenesis in the eye. Until now, its presence in tears has however not been reported. Our initial results, based on the analysis of diluted tear fluid samples, even indicated the absence of this factor in human tears. Because of the clinical importance of PEDF as a regulator of vascularisation, we decided to investigate undiluted human tear fluid.

Methods:: Samples of sixteen individuals were collected as previously described and analyzed using a commercial ELISA assay.

Results:: PEDF concentrations were below the detection limit (ie < 0,1ng/ml) in the majority of samples. However, PEDF was discovered in three of the samples taken with significant concentrations up to 53 ng/ml with a mean concentration of 29 ng/ml with repeated positive concentrations in one individual.

Conclusions:: PEDF may be found in measurable amounts in human tear fluid and may therefore also play a role in effects and regulation of PEDF at the ocular surface.

Keywords: cornea: tears/tear film/dry eye • lacrimal gland • neovascularization 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.