May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Prevention of Corneal Neovascularization by Anti-VEGF Therapy in an Experimental Rat Model
Author Affiliations & Notes
  • L. Hoffart
    Service Ophtalmologie, Hopital de la Timone, Marseille, France
    INCM UMR6193 CNRS, Marseille, France
  • F. Matonti
    Service Ophtalmologie, Hopital de la Timone, Marseille, France
  • F. Chavane
    INCM UMR6193 CNRS, Marseille, France
  • G. Masson
    INCM UMR6193 CNRS, Marseille, France
  • Hé. Proust
    Service Ophtalmologie, Hopital de la Timone, Marseille, France
  • B. Ridings
    Service Ophtalmologie, Hopital de la Timone, Marseille, France
    INCM UMR6193 CNRS, Marseille, France
  • J. Conrath
    Service Ophtalmologie, Hopital de la Timone, Marseille, France
    INCM UMR6193 CNRS, Marseille, France
  • Footnotes
    Commercial Relationships L. Hoffart, None; F. Matonti, None; F. Chavane, None; G. Masson, None; H. Proust, None; B. Ridings, None; J. Conrath, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1697. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      L. Hoffart, F. Matonti, F. Chavane, G. Masson, Hé. Proust, B. Ridings, J. Conrath; Prevention of Corneal Neovascularization by Anti-VEGF Therapy in an Experimental Rat Model. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1697. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To evaluate the effect of topically administeredanti-VEGF therapy on experimental corneal neovascularization in rats.

Methods:: Chemical cauterization of cornea was performed in 20eyes of 20 rats by using silver nitrate/potassium nitrate sticks. Cauterization was followed by a single subconjunctival injection of bevacizumab (avastin®) in 10 rats (group 1) and by a single subconjunctival injection of BSS in 10 rats (group 2). Percent areas of cornea covered by neovascularization and covered by scar in each group were calculated by use of computer software on digital photographs at J0, J7, J14, J21 and J28. Groups were compared for any significant (P , 0.05) differences among them. Animals were euthanized and cauterized eyes were enucleated and fixed in formaldehyde 10% for histologic examination using hematoxylinand eosin staining.

Results:: The bevacizumab (avastin®) group was different from control group (P , 0.05). There were no significant differences in percent area of corneal scar among groups. Further studies are needed to compare anti-VEGF therapy versus corticosteroids in preventing corneal neovacularization in rats after chemical cauterization .

Conclusions:: Topical instillation of bevacizumab (avastin®) seems to diminish corneal neovascularization caused by chemical cauterization of cornea in rats.

Keywords: cornea: clinical science • neovascularization • pathology: experimental 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×