May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Inhibition of Corneal Neovascularization by Blocking the Angiotensin II Type 1 Receptor
Author Affiliations & Notes
  • T. Usui
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • K. Sugisaki
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • S. Yokoo
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • S. Yamagami
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • S. Amano
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • N. Nagai
    Ophthalmology, Keio University, Tokyo, Japan
  • S. Ishida
    Ophthalmology, Keio University, Tokyo, Japan
  • Footnotes
    Commercial Relationships T. Usui, None; K. Sugisaki, None; S. Yokoo, None; S. Yamagami, None; S. Amano, None; N. Nagai, None; S. Ishida, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1715. doi:https://doi.org/
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    • Get Citation

      T. Usui, K. Sugisaki, S. Yokoo, S. Yamagami, S. Amano, N. Nagai, S. Ishida; Inhibition of Corneal Neovascularization by Blocking the Angiotensin II Type 1 Receptor. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1715. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in corneal neovascularization

Methods:: Corneal neovascularization was induced by suturing 10-0 nylon 1 mm away from limbal vessel in C57BL/6 mice. The expression of angiotensin II and AT1-R was evaluated by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), in situ PCR, and immunohistochemistry. To investigate the function of angiotensin II signalling in inflammatory corneal neovascularization, Telmisartan (AT1-R antagonist) or PBS (control) was administered intraperitonelly and neovascularized area was compared between control and treated mice.

Results:: Angiotensin II and AT1-R mRNA and protein markedly increased in the neovascularized corneas compared with normal corneas. Neovascularized area in cornea of Telmisartan-treated mice was significantly small compared with that of control mice on day 7 after corneal suture.

Conclusions:: AT1-R signaling inhibition by Telmisartan significantly attenuates corneal neovascularization, suggesting that termisartan may be a therapeutic target for suppression of corneal neovascularization.

Keywords: cornea: basic science • inflammation • neovascularization 
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