May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Anatomical Outcomes Following Treatment for Retinal Pigment Epithelium Detachment Associated With Age-Related Macular Degeneration
Author Affiliations & Notes
  • H. H. Kim
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • P. E. Carvounis
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • R. P. A. Manzano
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • J. A. Fortun
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • B. Chan-Kai
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • T. A. Albini
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • E. R. Holz
    Ophthalmology, Baylor College of Medicine, Houston, Texas
  • Footnotes
    Commercial Relationships H.H. Kim, None; P.E. Carvounis, None; R.P.A. Manzano, None; J.A. Fortun, None; B. Chan-Kai, None; T.A. Albini, None; E.R. Holz, None.
  • Footnotes
    Support Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1802. doi:https://doi.org/
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      H. H. Kim, P. E. Carvounis, R. P. A. Manzano, J. A. Fortun, B. Chan-Kai, T. A. Albini, E. R. Holz; Anatomical Outcomes Following Treatment for Retinal Pigment Epithelium Detachment Associated With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1802. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To report the frequency of retinal pigment epithelium tears following treatment of retinal pigment epithelium detachment (PED) associated age-related macular degeneration (ARMD) using photodynamic therapy (PDT), intravitreous triamcinolone acetonide (IVTK) or their combination (PDT+IVTK).

Methods:: Retrospective, comparative review of 33 eyes of 31 consecutive patients with ARMD-associated PEDs measuring more than 2/3 disc diameters, with initial visual acuity better than 20/200, treated with one or more sessions of PDT with Verteporfin, IVTK (4mg), or PDT+IVTK.

Results:: At 12 months, PEDs persisted in 80%, 87.5% and 50% of eyes in the PDT, IVTK and PDT+IVTK group (p=0.81) with RPE tears developing in 25% of eyes in the PDT+IVTK group compared to no eyes in the PDT or IVTK groups (p=0.04).

Conclusions:: PDT, IVTK, and PDT+IVTK are ineffective in resolving PEDs. PDT+IVTK results in a statistically significant increase in RPE tears compared to PDT or IVTK alone.

Keywords: age-related macular degeneration • retinal pigment epithelium • retina 
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