May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Corneal Hysteresis in Patients With Herpetic Stromal Scarring
Author Affiliations & Notes
  • B. L. Tannen
    Ophthalmology & Visual Science, UMDNJ -- New Jersey Medical School, Newark, New Jersey
  • J. D. Pruzon
    Ophthalmology & Visual Science, UMDNJ -- New Jersey Medical School, Newark, New Jersey
  • D. S. Chu
    Ophthalmology & Visual Science, UMDNJ -- New Jersey Medical School, Newark, New Jersey
  • Footnotes
    Commercial Relationships B.L. Tannen, None; J.D. Pruzon, None; D.S. Chu, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1857. doi:https://doi.org/
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      B. L. Tannen, J. D. Pruzon, D. S. Chu; Corneal Hysteresis in Patients With Herpetic Stromal Scarring. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1857. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate changes in Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF) in eyes with herpetic stromal scarring using the Reichert Ocular Response Analyzer (ORA). The ORA is a new technology which measures biomechanical properties of the cornea by means of a dynamic bi-directional applanation process. CH is stated to be a new independent measure of corneal tissue property. CRF, which is calculated from the CH, is stated to be a measure of the "resistance" of the cornea dependent on its structural integrity.

Methods:: Retrospective review identified 11 patients (5 men, 6 women) with monocular herpetic stromal scarring who had CH and CRF measurements taken in both the involved and normal eye using the ORA . The involved eyes were further subdivided by central versus peripheral scarring and the presence or absence of corneal neovascularization. Statistical analysis was performed on the collected data.

Results:: CH was significantly reduced in the eyes with herpetic stromal scarring (Average CH = 8.7, Standard Deviation = 2.0) compared with the normal eyes (Avg CH = 11.0, SD = 2.2). CRF was also significantly reduced in the involved eyes (Avg CRF 8.5, SD = 2.0) compared with the normal eyes (Avg CRF = 10.85, SD = 2.17). Eyes with central scarring demonstrated a significantly greater reduction in CH (Avg 21.6% reduction) and CRF (Avg 23.2% reduction) than eyes with peripheral scarring (Avg CH reduction = 11.6%, Avg CRF reduction 11.1%). Eyes with scaring and neovascularization did not show a significant difference in CH and CRF measurements than with scarring without neovascularization.

Conclusions:: Eyes with herpetic stromal scarring demonstrate a significant reduction in both CH and CRF. Central scaring leads to a larger reduction in CH and CRF than peripheral scarring. Neovascularization did not affect CH or CRF measurements in eyes with scarring.

Keywords: cornea: clinical science • cornea: stroma and keratocytes 
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