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B. L. Tannen, J. D. Pruzon, D. S. Chu; Corneal Hysteresis in Patients With Herpetic Stromal Scarring. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1857.
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To evaluate changes in Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF) in eyes with herpetic stromal scarring using the Reichert Ocular Response Analyzer (ORA). The ORA is a new technology which measures biomechanical properties of the cornea by means of a dynamic bi-directional applanation process. CH is stated to be a new independent measure of corneal tissue property. CRF, which is calculated from the CH, is stated to be a measure of the "resistance" of the cornea dependent on its structural integrity.
Retrospective review identified 11 patients (5 men, 6 women) with monocular herpetic stromal scarring who had CH and CRF measurements taken in both the involved and normal eye using the ORA . The involved eyes were further subdivided by central versus peripheral scarring and the presence or absence of corneal neovascularization. Statistical analysis was performed on the collected data.
CH was significantly reduced in the eyes with herpetic stromal scarring (Average CH = 8.7, Standard Deviation = 2.0) compared with the normal eyes (Avg CH = 11.0, SD = 2.2). CRF was also significantly reduced in the involved eyes (Avg CRF 8.5, SD = 2.0) compared with the normal eyes (Avg CRF = 10.85, SD = 2.17). Eyes with central scarring demonstrated a significantly greater reduction in CH (Avg 21.6% reduction) and CRF (Avg 23.2% reduction) than eyes with peripheral scarring (Avg CH reduction = 11.6%, Avg CRF reduction 11.1%). Eyes with scaring and neovascularization did not show a significant difference in CH and CRF measurements than with scarring without neovascularization.
Eyes with herpetic stromal scarring demonstrate a significant reduction in both CH and CRF. Central scaring leads to a larger reduction in CH and CRF than peripheral scarring. Neovascularization did not affect CH or CRF measurements in eyes with scarring.
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