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A. Poli, C. Sinapis, N. G. Strouthidis, D. F. Garway-Heath; The Spatial Pattern of Neuroretinal Rim Loss in Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1971.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the spatial pattern of decline in rim area (RA) in ocular hypertension as measured with the Heidelberg Retina Tomograph (HRT).
198 ocular hypertensive (OHT) were examined prospectively with the HRT from 1993-2001. One eye per subject was selected for analysis, with a median 10 (range 5-16) HRT mean topographies available for each eye, processed using the 320 µm reference plane. Linear regression analysis of RA over time was performed for each of the HRT Explorer pre-defined sectors; Temporal (T), Superotemporal (ST), Inferotemporal (IT), Nasal (N), Superonasal (SN) and Inferonasal (IN).The mean slope of RA loss (mm2/Year) in each sector was compared, as was the frequency of significant slopes in each sector.
IT slopes were greater than T, SN and IN slopes (p = 0.03, 0.01 and 0.03, respectively, paired t-test) and ST slopes were greater than SN slopes (p = 0.005, paired t-test).
Although there are significant differences in the rate of RA loss between some sectors, the differences are small, when considered as a percentage of total RA. A similar frequency of significant RA loss occurs in each sector with the exception of the temporal which may have greater localised variability. Our results indicate that a ‘typical’ pattern of glaucomatous RA loss with ST/IT damage occurring first, may be over-emphasised; such patterns may represent an extreme phenotype, rather than the norm.
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