May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Mechanical Properties of the Porcine Lens
Author Affiliations & Notes
  • M. A. Reilly
    Energy Enviromental and Chemical Engineering, Washington Univ - St Louis, Saint Louis, Missouri
    Research,
    Department of Veterans Affairs, JC Medical Center, St. Louis, Missouri
  • N. Ravi
    Energy Enviromental and Chemical Engineering, Washington Univ - St Louis, Saint Louis, Missouri
    Ophthalmology,
    Department of Veterans Affairs, JC Medical Center, St. Louis, Missouri
  • Footnotes
    Commercial Relationships M.A. Reilly, None; N. Ravi, None.
  • Footnotes
    Support NIH Core Grant P30 EY 02697; VA Merit Review Grant to Dr. Nathan Ravi; Research to Prevent Blindness, Inc.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2023. doi:https://doi.org/
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    • Get Citation

      M. A. Reilly, N. Ravi; The Mechanical Properties of the Porcine Lens. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2023. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine the local mechanical properties of the porcinelens locally using a novel indentation device.

 
Methods:
 

Fresh porcine lenses were fixed in a 2% agarose gel. The lenseswere then sectioned across the equatorial plane (Fig. 1) orthe polar plane (Figs. 2, 3). The indenter applied a compressiveload normal to the lens’ exposed surface. The local elasticmodulus was computed from force-displacement data assuming incompressibility.

 
Results:
 

The young porcine lens exhibits a modulus gradient. The maximummodulus occurs at the center of the nucleus and decreases towardsthe periphery and the poles. The modulus depended heavily onthe direction of indentation, indicating anisotropic behavior.

 
Conclusions:
 

Detailed knowledge of the elastic gradient of the lens is essentialfor proper mechanical modeling of accommodation and presbyopia.It is also important to consider that the gradient may be anintegral part of the lens’ behavior in accommodation andmay vary significantly with age in humans, potentially contributingto presbyopia. 

  

 
Keywords: intraocular lens • presbyopia • anterior segment 
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