May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
UVR Exposure and Risk of Neovascular Age-Related Macular Degeneration
Author Affiliations & Notes
  • A. J. Harring
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
  • A. M. Lane
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
    Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • M. A. Morrison
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
  • A. Copone
    Associated Retinal Consultants, PC, William Beaumont Hospital, Royal Oak, Michigan
  • T. P. Dryja
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
    Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • J. W. Miller
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
    Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • I. K. Kim
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
    Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • M. M. DeAngelis
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
  • Footnotes
    Commercial Relationships A.J. Harring, None; A.M. Lane, None; M.A. Morrison, None; A. Copone, None; T.P. Dryja, None; J.W. Miller, None; I.K. Kim, None; M.M. DeAngelis, None.
  • Footnotes
    Support The Ruth and Milton Steinbach Fund, the Lincy Foundation, the Knight AMD Fund, the Mass. Lions, Friends of the MEEI., Genetics of AMD Fund, Research to Prevent Blindness, NIH grants EY014458, EY14104
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2093. doi:https://doi.org/
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    • Get Citation

      A. J. Harring, A. M. Lane, M. A. Morrison, A. Copone, T. P. Dryja, J. W. Miller, I. K. Kim, M. M. DeAngelis; UVR Exposure and Risk of Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2093. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Findings have not been in agreement as to a causative or protective effect of sunlight exposure on risk of age-related macular degeneration (AMD). Therefore we evaluated UVR (Ultraviolet Radiation) Index, UV-A, and UV-B as a measure of sunlight exposure on risk of neovascular AMD.

Methods:: We obtained epidemiological data by conducting telephone or in-person standardized interviews with 135 extremely discordant sibpairs (index case with neovascular AMD [mean age = 71.4 yrs] and sibling with normal maculae past the age of diagnosis of the index patient [mean age = 72.8 yrs]) from 135 families. Disease status was ascertained by two investigators by review of fundus photographs. If necessary, a home retinal examination was performed (n =6). Exposure data were measured up to the age of AMD diagnosis of the index subject. We determined UVR index, UV-A, and UV-B measures by inputting the city and state at which the individual resided for the majority of his or her lifetime using the following website: http://cprm.acd.ucar.edu/Models/TUV/Interactive_TUV/. This calculator uses longitude, latitude and elevation to estimate UVR levels. We assessed the relationship between neovascular AMD and UVR levels using McNemar’s test.

Results:: A decrease in risk of neovascular AMD was observed in subjects with lifetime UV index exposure greater than or equal to 3.0 when compared to those with a UV index of less than 3.0 (OR: 0.23, 95% CI: 0.08-0.52, p =.0002), (number of informative sibpairs: n = 38). Similar results were obtained when we caluclated UV-A or UV-B exposures separately. Individuals with a lifetime UV-B exposure of 0.60 or greater compared to individuals who had measures less than 0.60, had a 14-fold reduction in risk of neovascular AMD (p < 0.001.), (number of informative sibpairs: n = 30). Subjects with a lifetime UV-A exposure of 31.6 or greater compared to those with a measure of less than 31.6 had a 2.7 fold decrease in risk ( p = 0.009), (number of informative sibpairs: n = 37) .

Conclusions:: In this cohort of extremely discordant sibpairs, preliminary analysis revealed that subjects who were exposed to higher UVR levels (UVR Index, UV-A, or UV-B) for the majority of their lifetimes were less likely to develop neovascular AMD than subjects who were exposed to lower UVR levels.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: risk factor assessment • radiation damage: light/UV 
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