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B. R. Hammond, Jr., J. S. Stringham, J. M. Nolan, B. R. Wooten, M. Snodderly; The Validity of Macular Pigment Measurements Using HFP in Patients With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2135.
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To assess the validity of measuring macular pigment optical density (MP OD) in patients with early age-related macular degeneration (AMD) using heterochromatic flicker photometry (HFP). The validity criteria were based on the similarity of the spectral absorption curves to ex vivo curves of lutein and zeaxanthin and the similarity of spatial density profiles to those seen in subjects without retinal disease.
Standard Maxwellian view optics and the macular densitometer were used to measure MP spatial density and spectral absorption curves. 34 AMD subjects with normal color vision and one protanope were tested. All subjects were characterized via clinical exams and blinded grading of color fundus photographs using the Wisconsin Age-Related Maculopathy Grading System.
Spatial density profiles were measured in 19 subjects. These profiles were highly similar to those that have been measured in subjects without retinal disease when using HFP. The shape of the spectral absorption curves for the AMD subjects corresponded well to an ex vivo template.
These data support the validity of the HFP method for measuring MP density in subjects with early AMD.
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