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T. T. Berendschot, R. L. van der Veen, D. Carden, D. van Norren, I. Murray; Desktop Macular Pigment Optical Density Measurement: A New Approach Based on Heterochromatic FlickerPhotometry. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2138.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate a new way of exploiting the technique of heterochromatic flickerphotometry to determine the macular pigment optical density (MPOD).
The Macular Pigment Screener (called QuantifEYE in the USA) is designed to assess MPOD under clinical conditions. It employs a new technique for obtaining the minimum flicker point whereby observers press a button when they detect flicker. This contrasts with the more conventional approach of adjusting a luminance ratio until flicker is eliminated. Twenty-two healthy subjects, age 22-64 years, participated in the study. Measurements were repeated 5 times. Another series of 5 measurements were obtained in a subset of subjects after an interval of at least three days. Macular pigment was also measured by spectral fundus reflectance, and with a scanning laser ophthalmoscope. The latter used both reflectance maps and autofluorescence maps to obtain the spatial distribution of the macular pigment.
Measurements were successfully completed in all subjects. Mean MPOD on the Macular Pigment Screener was 0.41 ± 0.17, mean within subjects variation was 0.063 ± 0.028. Correlation between the Macular Pigment Screener and spectral fundus reflectometry was r = 0.85 (p<0.001).
The Macular Pigment Screener provides fast, reliable, accurate MPOD data. It can be readily operated by non-professional staff under office/clinical conditions. The instrument holds great promise for large-scale epidemiological study of the macular pigment.
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