May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Desktop Macular Pigment Optical Density Measurement: A New Approach Based on Heterochromatic FlickerPhotometry
Author Affiliations & Notes
  • T. T. Berendschot
    University Eye Clinic Maastricht, Maastricht, The Netherlands
  • R. L. van der Veen
    University Eye Clinic Maastricht, Maastricht, The Netherlands
  • D. Carden
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
  • D. van Norren
    Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
  • I. Murray
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
  • Footnotes
    Commercial Relationships T.T. Berendschot, ZeaVision, L.L.C., F; R.L. van der Veen, ZeaVision, L.L.C., F; D. Carden, Macular Pigment Screener, P; D. van Norren, None; I. Murray, Macular Pigment Screener, P.
  • Footnotes
    Support ZeaVision, L.L.C.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2138. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T. T. Berendschot, R. L. van der Veen, D. Carden, D. van Norren, I. Murray; Desktop Macular Pigment Optical Density Measurement: A New Approach Based on Heterochromatic FlickerPhotometry. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2138. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To evaluate a new way of exploiting the technique of heterochromatic flickerphotometry to determine the macular pigment optical density (MPOD).

Methods:: The Macular Pigment Screener (called QuantifEYE in the USA) is designed to assess MPOD under clinical conditions. It employs a new technique for obtaining the minimum flicker point whereby observers press a button when they detect flicker. This contrasts with the more conventional approach of adjusting a luminance ratio until flicker is eliminated. Twenty-two healthy subjects, age 22-64 years, participated in the study. Measurements were repeated 5 times. Another series of 5 measurements were obtained in a subset of subjects after an interval of at least three days. Macular pigment was also measured by spectral fundus reflectance, and with a scanning laser ophthalmoscope. The latter used both reflectance maps and autofluorescence maps to obtain the spatial distribution of the macular pigment.

Results:: Measurements were successfully completed in all subjects. Mean MPOD on the Macular Pigment Screener was 0.41 ± 0.17, mean within subjects variation was 0.063 ± 0.028. Correlation between the Macular Pigment Screener and spectral fundus reflectometry was r = 0.85 (p<0.001).

Conclusions:: The Macular Pigment Screener provides fast, reliable, accurate MPOD data. It can be readily operated by non-professional staff under office/clinical conditions. The instrument holds great promise for large-scale epidemiological study of the macular pigment.

Keywords: macular pigment • age-related macular degeneration • clinical (human) or epidemiologic studies: systems/equipment/techniques 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×