May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Macular Pigment Optical Density (MPOD), Serum C-Reactive Protein (CRP), and Serum Lutein and Zeaxanthin (L&Z) in Age-Related Maculopathy (ARM)
Author Affiliations & Notes
  • A. Iannaccone
    UTHSC, Memphis, Tennessee
    Ophthalmology/Hamilton Eye Institute,
  • E. J. Johnson
    J. Mayer USDA Human Nutrition Research Ctr. on Aging, Tufts Univ., Boston, Massachusetts
  • K. T. Gallaher
    UTHSC, Memphis, Tennessee
    Ophthalmology/Hamilton Eye Institute,
  • J. Armstrong
    Ophthalmology & Vis. Sci., Univ. Wisconsin, Madison, Wisconsin
  • E. Kenyon
    Epidemiology & Biostatistics, UCSF, San Francisco, California
  • T. Harris
    NIA, NIH, Bethesda, Maryland
  • K.-J. Yeum
    J. Mayer USDA Human Nutrition Research Ctr. on Aging, Tufts Univ., Boston, Massachusetts
  • S. Satterfield
    UTHSC, Memphis, Tennessee
    Preventive Medicine,
  • K. C. Johnson
    UTHSC, Memphis, Tennessee
    Preventive Medicine,
  • S. B. Kritchevsky
    UTHSC, Memphis, Tennessee
    Preventive Medicine,
    J.P. Sticht Ctr. on Aging, Wake Forest Univ., Winston-Salem, North Carolina
  • Footnotes
    Commercial Relationships A. Iannaccone, Bausch & Lomb; Kemin Foods, F; E.J. Johnson, DSM, F; K.T. Gallaher, None; J. Armstrong, None; E. Kenyon, None; T. Harris, None; K. Yeum, None; S. Satterfield, None; K.C. Johnson, None; S.B. Kritchevsky, None.
  • Footnotes
    Support NIH K23 EY000409 HIGHWIRE EXLINK_ID="48:5:2147:1" VALUE="EY000409" TYPEGUESS="GEN" /HIGHWIRE , N01 AG62101, N01 AG62103, N01 AG62106, T35 DK07405; IRRF; RPB; AHAF; DSM; Bausch & Lomb; Kemin Foods.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2147. doi:https://doi.org/
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      A. Iannaccone, E. J. Johnson, K. T. Gallaher, J. Armstrong, E. Kenyon, T. Harris, K.-J. Yeum, S. Satterfield, K. C. Johnson, S. B. Kritchevsky; Macular Pigment Optical Density (MPOD), Serum C-Reactive Protein (CRP), and Serum Lutein and Zeaxanthin (L&Z) in Age-Related Maculopathy (ARM). Invest. Ophthalmol. Vis. Sci. 2007;48(13):2147. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To report the relationship between MPOD and serum levels of CRP and L&Z in subjects with ARM.

Methods:: We studied 112 subjects with ARM [mean age: 79.4 yo, 90% White, 56% females, 46% lutein supplement users (LSUs)] participating in ARMA, an ancillary study to Health ABC. Fundus features were graded in a blinded fashion. By most severely affected eye criteria, the majority of ARM cases met the definition for AREDS category 3 (76%). MPOD estimates could be obtained by heterochromatic flicker photometry at 0.5 degrees of eccentricity from the fovea in 83 (74%) of the affected participants (96% of which had AREDS category 3 ARM). Fasting serum samples were collected at time of visit and analyzed according to standardized protocols. L&Z and CRP were not normally distributed and were ln-transformed.

Results:: The proportion of LSUs was the same in controls and in newly diagnosed cases of ARM (37%). MPOD in newly diagnosed cases (0.34 +/- 0.20, n=71) was not different from controls (0.35 +/- 0.21), despite serum ln-levels of L&Z (2.87 +/- 0.56 ug/dl) and CRP (1.19 +/- 1.08 ug/ml) being respectively lower (p=0.014) and marginally higher (p=0.044) in ARM than in controls (ln-L&Z: 3.05 +/- 0.47 ug/dl; ln-CRP: 0.70 +/- 1.24 ug/ml). Compared to controls, serological differences were significantly greater in bilateral cases (n=37) of newly diagnosed ARM (ln-L&Z: 2.78 +/- 0.57 ug/dl, p=0.005; ln-CRP: 1.53 +/- 1.04 ug/ml, p=0.003). The proportion of LSUs in previously diagnosed cases of ARM (n=41) was twice as large (63%). Consistent with this pattern, both serum ln-L&Z (3.36 +/- 0.62 ug/dl, p=0.001) and MPOD (0.44 +/- 0.20, p=0.024) in previously diagnosed cases of ARM were significantly higher than controls, and ln-CRP was no longer significantly higher than in controls (1.08 +/- 1.04 ug/ml, p=0.271).

Conclusions:: In newly diagnosed cases of ARM, MPOD is not reduced despite serological evidence of reduced L&Z levels. Higher CRP levels in bilateral ARM suggest that circulating CRP is an indicator of inflammation that is proportional to the extent of macular disease. On average, MPOD of subjects with ARM appears to remain responsive to L&Z dietary supplementation. L&Z intake modifies CRP levels and confounds association studies of ARM.

Keywords: macular pigment • age-related macular degeneration • inflammation 
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