May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Laser Induced Resolution of Drusen Is Associated With Increases in Choroidal Blood Flow
Author Affiliations & Notes
  • T. I. Metelitsina
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • M. Figueroa
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • L. S. Schocket
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • G.-S. Ying
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • J. C. DuPont
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • J. Alexander
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • J. E. Grunwald
    Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships T.I. Metelitsina, None; M. Figueroa, None; L.S. Schocket, None; G. Ying, None; J.C. DuPont, None; J. Alexander, None; J.E. Grunwald, None.
  • Footnotes
    Support NIH EY012769 HIGHWIRE EXLINK_ID="48:5:2150:1" VALUE="EY012769" TYPEGUESS="GEN" /HIGHWIRE , EY001583 HIGHWIRE EXLINK_ID="48:5:2150:2" VALUE="EY001583" TYPEGUESS="GEN" /HIGHWIRE , EY 12279, Vivian S. Lasko Research Fund, Nina C. Mackall Trust, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2150. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T. I. Metelitsina, M. Figueroa, L. S. Schocket, G.-S. Ying, J. C. DuPont, J. Alexander, J. E. Grunwald; Laser Induced Resolution of Drusen Is Associated With Increases in Choroidal Blood Flow. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2150. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To investigate the relationship between laser-induced resolution of drusen and choroidal blood flow changes in the Complication of Age-Related Macular Degeneration Prevention trial (CAPT).

 
Methods:
 

We investigated 23 CAPT patients (14 female, mean (SD) age: 71.4 (4.95)) with ≥ 10 bilateral drusen (>125µ) who received photocoagulation in one randomly selected eye at the University of Pennsylvania. Fundus photographs were obtained and laser Doppler flowmetry (Oculix) was used to assess relative foveolar choroidal blood velocity (ChBvel), volume (ChBVol), and flow (ChBFlow) in both eyes prior to laser administration, and again at 24 to 36 months (average: 28 months) after laser treatment. Trained readers at the CAPT Reading Center graded fundus photographs obtained at baseline, 24 and 36 months visits. The photographs were evaluated for percent area of baseline drusen reduction within 3000 µ of the fovea. Treated eyes were divided into two groups according to the resolution of drusen. In comparison to baseline drusen, group 1 showed ≥ 50% reduction (N=9) and group 2 showed < 50% reduction (N=14). Choroidal blood flow changes from baseline were compared between these two groups. Analysis of all data was performed in a masked fashion. Circulatory measurements are shown as mean (SE) in arbitrary units (AU).

 
Results:
 

At 24 to 36 months after laser photocoagulation, eyes with more baseline drusen resolution had significantly larger increases in ChBVel, ChBVol and ChBFlow than those with less drusen resolution.Multivariate analysis adjusted by age and IOP showed similar results for ChBVel (P =0.04), ChBVol (P =0.01), and ChBFlow (P =0.003).  

 
Conclusions:
 

Eyes that show more drusen reduction following laser treatment have larger increases in choroidal circulatory parameters suggesting that circulatory increases may play a role in the mechanisms that results in the resolution of drusen.

 
Keywords: age-related macular degeneration • laser • drusen 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×