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F. Mojana, A. M. Tammewar, D.-U. Bartsch, N. Nigam, I. Kozak, L. Cheng, W. R. Freeman; Advantages of Ultra High Speed/Extremely High Resolution Spectral OCT versus Conventional Stratus OCT in Imaging Age Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2154. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the ability to delineate and localize age macular degeneration (AMD) changes seen with extremely high resolution (6 microns) ultrahigh speed Spectral optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO) imaging and Stratus OCT and to evaluate response of choroidal neovascularization (CNV) to bevacizumab (Avastin) therapy.
forty-eight eyes with AMD and related pathologies (pigment epithelial detachment (PED), central serous retinopathy (CSR)) were imaged within 7 days by simultaneous Spectral OCT/SLO (OTI Inc, Toronto, Canada) and Stratus OCT (Carl ZEISS Meditec Inc, Dublin, CA, USA) with raster scan mode (24 horizontal sections through the macula). The goal was to localize and quantify (using a numerical grading system) drusen, photoreceptor structure, retinal pigment epithelium (RPE) abnormalities, CNV membranes, presumed CNV and PED-induced outer retinal fluid and choriocapillaris vasculature.
Spectral OCT/SLO was superior to Stratus OCT in detecting drusen (median 2 vs 1, mean+/-sd 2+/-0 vs 1.11+/-0.63 respectively, p<0.001), outer retinal fluid (median 1 vs 1, mean+/-sd 1.17+/-0.83 vs 0.65+/-1.7 respectively, p=0.032) and disruptions of photoreceptor layers (median 1 vs 1, mean+/-sd 0.9+/-0.3 vs 0.75+/-0.44 respectively, p=0.029). Areas of RPE atrophy, subtle RPE disruptions, CNV details and choriocapillaris vasculature were strikingly better delineated using Spectral OCT/SLO.
Simultaneous Spectral OCT/SLO in AMD has advantages over conventional Stratus OCT even using raster horizontal sections with Stratus OCT device.Small drusen imaging, small amounts of CNV induced outer retinal fluid, and disruption of photoreceptor layers could be better seen with Spectral OCT. This appears to be thanks to high speed of Spectral OCT, with less motion artifacts, increased number of cuts and higher resolution. In addition Spectral OCT/SLO may better visualize changes in CNV, quantify fluid and analyze outer retinal structures in patients treated with antiangiogenic therapy.
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