May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Differences in Cytokine Pattern Production in Adults and Children With Vernal Keratoconjunctivitis
Author Affiliations & Notes
  • V. Deligianni
    Neuroscience, Ophthalmology Unit, University of Padua, Padova, Italy
  • S. J. Curnow
    Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom
  • M. Bortolotti
    Neuroscience, Ophthalmology Unit, University of Padua, Padova, Italy
  • V. L. Calder
    Clinical Ophthalmology, UCL, London, Italy
  • A. G. Secchi
    Neuroscience, Ophthalmology Unit, University of Padua, Padova, Italy
  • A. A. Leonardi
    Neuroscience, Ophthalmology Unit, University of Padua, Padova, Italy
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2302. doi:
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    • Get Citation

      V. Deligianni, S. J. Curnow, M. Bortolotti, V. L. Calder, A. G. Secchi, A. A. Leonardi; Differences in Cytokine Pattern Production in Adults and Children With Vernal Keratoconjunctivitis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2302.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Vernal keratoconjunctivitis (VKC) rarely presents as a new disease in adults. In order to evaluate if the cytokine pattern production was different in adults and children with VKC, multiple cytokines were assayed in tears of different subgroups of VKC patients.

Methods:: Tears were collected from 24 active VKC patients: 9 adults and 16 children, as well as 8 normal subjects (CT). Tears were centrifuged and probed using the multiplex bead analysis for IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, GM-CSF, IFNγ and TNFα.

Results:: Considering all VKC patients, IL-4, IL-6, IL-8 and IL-10 levels were increased in VKC compared to CT. No differences in cytokine levels were found after classifying all patients by type of VKC: limbal or tarsal. However, in children, IL-6 was significantly increased in tarsal compared to limbal VKC. In adults, IL-1, IL-2, IL-12, IFNγ and GM-CSF levels were all higher in limbal compared to tarsal VKC. As found in previous studies, no differences in cytokine production were found between prick/IgE+ and prick/IgE- patients with either tarsal or limbal VKC.

Conclusions:: Cytokine pattern production is similar in children and adults with VKC. Nevertheless, in the adult subgroup, a more pronounced Th1-type cytokine pattern production was found in the limbal form of the disease.

Keywords: conjunctivitis • cytokines/chemokines • cornea: tears/tear film/dry eye 
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