May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Myopia Stabilization in the Correction of Myopia Evaluation Trial (COMET) Cohort
Author Affiliations & Notes
  • L. Dong
    Stony Brook Univ, Stony Brook, New York
  • J. Gwiazda
    New England College of Optometry, Boston, Massachusetts
  • L. Hyman
    Stony Brook Univ, Stony Brook, New York
  • D. Kurtz
    New England College of Optometry, Boston, Massachusetts
  • R. Manny
    Univ of Houston College of Optometry, Houston, Texas
  • W. Marsh-Tootle
    Univ of Alabama at Birmingham School of Optometry, Birmingham, Alabama
  • M. Scheiman
    Pennsylvania College of Optometry, Philadelphia, Pennsylvania
  • D. Everett
    NEI, Bethesda, Maryland
  • COMET Group
    Stony Brook Univ, Stony Brook, New York
  • Footnotes
    Commercial Relationships L. Dong, None; J. Gwiazda, None; L. Hyman, None; D. Kurtz, None; R. Manny, None; W. Marsh-Tootle, None; M. Scheiman, None; D. Everett, None.
  • Footnotes
    Support NIH Grant EY11805, EY11756.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2385. doi:
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      L. Dong, J. Gwiazda, L. Hyman, D. Kurtz, R. Manny, W. Marsh-Tootle, M. Scheiman, D. Everett, COMET Group; Myopia Stabilization in the Correction of Myopia Evaluation Trial (COMET) Cohort. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2385.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: 1) To describe myopia stabilization after 7 yrs of follow-up in COMET participants based on Gompertz curve fits to each subject’s refractive error data; 2) To evaluate the association between myopia stabilization and age, gender, and ethnicity.

Methods:: 469 myopic, ethnically diverse, 6-11 yr old (median age 9 yrs) children who enrolled in COMET in 1997-1998 continued to be followed after the clinical trial phase ended. Non-cycloplegic autorefraction measurements were collected semi-annually for 4 yrs and annually thereafter. The Gompertz function R=Re+Rc*(0.07295)^a^(x-t0), where R is the spherical equivalent refractive error (SER) at age x, was fit to the right eye SER for each subject. Myopia was considered as stable at a visit and subsequent visits once the data point at that visit was within ±0.25D of the asymptote of the curve. The status of subjects whose SER could not be fit by the Gompertz function was determined by agreement of two independent investigators; subjects whose status at a visit could not be determined as either stable or progressing were excluded for that visit. Associations between 7-yr stabilization and SER, age, gender and ethnicity were evaluated using the t-test or Χ2 test.

Results:: Stable myopia in COMET participants increased from 14% (58/418) at yr 3 (median age 12 yrs) to 50% (206/411) at yr 7 (median age 16 yrs). Of the 420 subjects with SER data at yr 7, 411 had myopia stabilization status defined-387 based on Gompertz fits and 24 based on investigator judgment. At yr 7, SER was lower in those subjects with stable (mean±SD= –4.3±1.5D) vs. progressing myopia (–5.5±1.6D), p<0.0001, even though their baseline SER was similar (–2.6±0.77D and –2.5±0.86D, respectively). The percent with stable myopia increased with age, from 35% (14/40) for 13-14 year olds to 63% (52/82) for 18 yr olds (p=0.04). In addition, the percent with stable myopia differed by ethnicity (p=0.01): 63% (71/113) in African-Americans, 46% (85/184) in Whites, and 38% (24/64) in Hispanics. The frequency of stable myopia was similar for males and females.

Conclusions:: At a median age of 16 yrs, 50% of COMET cohort had stable myopia mainly based on Gompertz curve fits, with older or African-American subjects more likely to have stable myopia. Longer follow-up is needed in order to obtain unbiased estimates of age and amount of myopia at stabilization for this cohort.

Clinical Trial:: NCT00000113

Keywords: myopia • clinical (human) or epidemiologic studies: natural history • clinical (human) or epidemiologic studies: risk factor assessment 

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