May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Structure Versus Function in Patients With Anterior Ischemic Optic Neuropathy (AION): A Test of a Linear Model
R. H. Kardon; D. Hood; J. Rouleau; S. Anderson; A. S. Wenick; P. Deng; L. Grover; Q. Ghadiali; M. M. Behrens; J. Odel
Author Affiliations & Notes
  • R. H. Kardon
    Ophthalmology and Visual Sciences, Univ of Iowa Hosp & Clinics and Veterans Administration, Iowa City, Iowa
  • D. Hood
    Departments of Psychology and Ophthalmology,
    Columbia University, New York, New York
  • J. Rouleau
    Ophthalmology and Visual Sciences, Univ of Iowa Hosp & Clinics and Veterans Administration, Iowa City, Iowa
  • S. Anderson
    Ophthalmology and Visual Sciences, Univ of Iowa Hosp & Clinics and Veterans Administration, Iowa City, Iowa
  • A. S. Wenick
    Departments of Psychology and Ophthalmology,
    Columbia University, New York, New York
  • P. Deng
    Department of Psychology,
    Columbia University, New York, New York
  • L. Grover
    Department of Psychology,
    Columbia University, New York, New York
  • Q. Ghadiali
    Department of Psychology,
    Columbia University, New York, New York
  • M. M. Behrens
    Department of Ophthalmology,
    Columbia University, New York, New York
  • J. Odel
    Department of Ophthalmology,
    Columbia University, New York, New York
  • Footnotes
    Commercial Relationships R.H. Kardon, None; D. Hood, None; J. Rouleau, None; S. Anderson, None; A.S. Wenick, None; P. Deng, None; L. Grover, None; Q. Ghadiali, None; M.M. Behrens, None; J. Odel, None.
  • Footnotes
    Support Supported by National Eye Institute grants R01-EY-09076 and RO1-EY-02115, VA Merit Review and Rehabilitation Division, unrestricted grant from Research to Prevent Blindness, NY, NY.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2459. doi:
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      R. H. Kardon, D. Hood, J. Rouleau, S. Anderson, A. S. Wenick, P. Deng, L. Grover, Q. Ghadiali, M. M. Behrens, J. Odel; Structure Versus Function in Patients With Anterior Ischemic Optic Neuropathy (AION): A Test of a Linear Model. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2459.

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Abstract

Purpose:: To test a linear model [1,2] relating the regional loss in retinal nerve fiber (RNFL) thickness measured with optical coherence tomography (OCT) to the corresponding regional loss in sensitivity measured with standard automated perimetry (SAP) from eyes with previous anterior ischemic optic neuropathy (ION).

Methods:: 24 individuals with anterior ischemic optic neuropathy (ION) (59.2±9.8 yrs) and 20 with normal vision (54.8±10.7 yrs) were tested. Time since acute ION ranged from 4.6 months to over 20.3 years (median of 2.8 years). All eyes had OCT RNFL thickness (fast circular scan, OCT3, Zeiss Meditech) and SAP (24-2 SITA standard, Zeiss Meditech) tested. Superior and inferior field regions, and corresponding disc sectors, were defined [3]. The average RNFL thickness of inferior and superior disc sectors was plotted against the average total deviations (linear units) of the corresponding field regions and a model fitted to these data. According to the model, the RNFL thickness R = sT + b, where T is the relative SAP sensitivity loss (on a linear scale, e.g. for -3dB, T=0.5), s is the RNFL thickness attributable to axons in the healthy/normal state and b is the residual RNFL measured when all sensitivity and axons are lost.

Results:: The data for the ION patients were described by the same curve, previously fitted to the data from patients with glaucoma. For patients with arcuate losses greater than -15 dB, the RNFL thickness provides an estimate of b for the individual. This estimated value of b was essentially the same as the value for glaucoma [2]. Further, it does not appear to change much, if any, during the atrophic, chronic stage (i.e. after 4.6 months) of ION.

Conclusions:: The linear model, which fits data from glaucoma eyes [1,2], also provided a good fit of the RNFL loss vs. SAP field loss in ION. The residual RNFL thickness did not change after the acute stage of ischemic attack had subsided, suggesting a constant contribution from glial cells. The success of the model provides a framework for relating structural to functional damage in optic nerve diseases. 1. Hood JOSA (in press); 2. Hood, Anderson, Wall & Kardon (under review); 3. Garway-Heath et al, Ophthal (2000)

Keywords: neuro-ophthalmology: optic nerve • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual fields 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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