Abstract
Purpose::
To compare the ability of scanning laser polarimeter (SLP) with variable corneal compensation (GDx VCC) and optical coherence tomograph (Stratus OCT) to discriminate between eyes with band atrophy (BA) of the optic nerve and healthy eyes.
Methods::
The study included 37 eyes with BA and temporal visual field (VF) defects from chiasmal compression and 29 normal eyes. Subjects underwent standard automated perimetry (SAP) and retinal nerve fibre layer (RNFL) scans using GDx VCC and Stratus OCT. The severity of the VF defects was evaluated by the temporal mean defect (TMD), calculated as the average of 22 values of the temporal total deviation plot on SAP. Receiver operating characteristic (ROC) curves were calculated. Pearson’s correlation coefficients were used to evaluate the relationship between RNFL thickness parameters and the TMD.
Results::
No significant difference was found between the ROC curves areas (AUCs) for the GDx VCC and Stratus OCT with regard to average RNFL thickness (0.98 and 0.99 respectively) and the superior (0.94; 0.95), inferior (0.96;0.97) and nasal (0.92;0.96) quadrants. However, the AUC in the temporal quadrant (0.77) was significantly smaller (p<0.001) with GDx VCC than with Stratus OCT (0.98). Lower TMD values were associated with smaller RNFL thickness in most parameters from both equipments.
Conclusions::
Adding VCC resulted in improved performance in SLP when evaluating eyes with BA and both technologies are sensitive in detecting average, superior, inferior and nasal quadrant RNFL loss. However, GDx VCC still poorly discriminate RNFL loss in the temporal quadrant when compared to Stratus OCT.
Clinical Trial::
www.clinicaltrials.gov NCT00395122
Keywords: optic nerve • nerve fiber layer • neuro-ophthalmology: diagnosis