May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Transretinal Fixation of Polyimides Strips
Author Affiliations & Notes
  • L. Lima
    Ophthalmology, Doheny Eye Institute, Kech School of Medicine, University of Southern California, Los Angeles, California
  • J. Wang
    Ophthalmology, Doheny Eye Institute, Kech School of Medicine, University of Southern California, Los Angeles, California
  • W. Liu
    Ophthalmology, Doheny Eye Institute, Kech School of Medicine, University of Southern California, Los Angeles, California
  • J. Weiland
    Ophthalmology, Doheny Eye Institute, Kech School of Medicine, University of Southern California, Los Angeles, California
  • R. Agrawal
    Ophthalmology, Doheny Eye Institute, Kech School of Medicine, University of Southern California, Los Angeles, California
  • M. Humayun
    Ophthalmology, Doheny Eye Institute, Kech School of Medicine, University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships L. Lima, None; J. Wang, None; W. Liu, None; J. Weiland, None; R. Agrawal, None; M. Humayun, None.
  • Footnotes
    Support NSF Grant EEC 0310723
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2569. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      L. Lima, J. Wang, W. Liu, J. Weiland, R. Agrawal, M. Humayun; Transretinal Fixation of Polyimides Strips. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2569.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To study long term effects of transretinal fixation of polyimide strips.

Methods:: Polyimide strips of 2 different lengths were inserted into subretinal space in pigmented rabbits, after a routine 2-port vitrectomy. In group A ( 7 rabbits), the strip was 6 x 0.5 mm, while in group B (10 rabbits), it was 4 x 0.5 mm. Group B rabbits received laser photocoagulation around the retinotomy site. The rabbits were followed up for 6 months, with routine evaluations like indirect ophthalmoscopy, intraocular pressure measurements, fundus photography, fluorescein angiography (FA) and optical coherence tomography (OCT). Rabbits were euthanized in the event of failed surgery or retinal detachment.

Results:: Fifteen of 17 rabbits underwent successful subretinal implantation of the strip. The polyimide strip created sufficient retinotomy in all cases. There were no immediate complications noticed on follow-up, including dislocation, vitreous hemorrhage or retinal detachment. Subretinal fluid was noticed around the retinotomy site in fewer cases in group B compared to group A. Four of 7 cases in group A had strip dislocation (average time: 4.5 months), while one of 8 cases in group B showed dislocation (average time: 3 months). FA or OCT did not reveal any significant findings. Gross ocular examination after euthanasia did not reveal any significant changes like retinal detachment or proliferative vitreoretinopathy.

Conclusions:: Polyimide strips of specific lenghts can be surgically inserted into the subretinal space and show stable localization, without significant side-effects. Further work is in progress to study other methods of fixation and electrical stimulation.

Keywords: retina • low vision • retinal connections, networks, circuitry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×