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R. M. Awdeh, A. Koreishi, E. Davies, M. Stopa, B. Bower, J. A. Izatt, C. Toth; High-Speed, High-Resolution Spectral Domain OCT Improves Imaging, Localization, and Quantification of Macular Pathology in AMD. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2600.
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Compare retinal pathology images determined from three-dimensional high-speed, high resolution spectral domain optical coherence tomography (SDOCT) to that of conventional optical coherence tomography in patients with age-related macular degeneration (AMD).
Forty nine eyes of 28 eligible patients had both conventional and spectral domain OCT imaging. The superluminescent diode source for SDOCT was at 840 nm (Δ = 49 nm, coherence length in tissue 4.7µm). A 3D block of 100 retinal scans was acquired in 5.7 seconds. SDOCT images were captured at a rate of 20,000 A-scans per second. Images were interpreted for several criteria including drusen, cystoid macular edema, subretinal fluid, pigment epithelial detachment (PED), retinal pigment epithelium atrophy, and photoreceptor layer thinning.
Critical AMD pathology not resolved on conventional imaging could be resolved with SDOCT. This included extent of disease and composition of components of disease (ie drusen and PED composition).
SDOCT allows for enhanced imaging including extent of disease and composition of AMD pathology in the macula. Further, this technology allows for quantifiable monitoring of disease progression and response to therapy.
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