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E. Cornand, D. Dauletbekov, Jr., R. Coste, Jr., E. Hadjadj, Sr., D. Denis, Sr.; Assessment of Specular Microscopy in Children With or Without Ametropia. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2690.
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© ARVO (1962-2015); The Authors (2016-present)
To assess endothelial cell density and central corneal thickness in children and to give standard values of these parameters in connection to age and refraction
Non-contact specular microscopy with the Topcon SP-2000P was performed in 405 eyes of children aged from 3 to 16 years old. Mean endothelial cell density (ECD), endothelial cell area (ECA), coefficient of variation in cell size (CV), percentage of hexagonal cells (H) and pachymetry (P) were recorded and analyzed in age and refraction groups.
Mean ECD was 3466 ± 357.2 cells per mm2, ECA was 288,4 ±µm2 and pachymetry was 529.3 ± 32.5 µm in our global population. Mean CV is 32.6 ± 10 % and mean hexagonality is 64.5 ± 12 %. There is a correlation between age and an ECD decrease on the one hand, and an ECA increase on the other hand. Moreover, ECD of myopic group is lower than that of the other refractive groups. Central pachymetry is not different between age groups but is lower in myopic group (520 ± 32µm) than in emetropic (523 ± 33µm) and hyperopic (533 ± 31µ) groups.
Few studies have been done on this subject and none have studied children with this type of technic. Variations of ECD and ECA in connection to age and refraction were found as it is in adult groups. In the same manner, central corneal thickness were found different in refraction groups, but not in age groups which is correlated to adult findings. So these parameters can be precisely estimated with a technical method perfectly adapted to this population, and we know the importance of this value in the management of illnesses such as glaucoma.
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