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N. Harizman, L. Schneider, C. Tello, R. Ritch, J. M. Liebmann, E. Chiu, D. C. Ritterband, J. A. Seedor; Confocal Microscopy of the Contralateral Eye in Unilateral Iridocorneal Endothelial Syndrome. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2702.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the endothelial cell layer of the contralateral, clinically uninvolved eye in patients with iridocorneal endothelial (ICE) syndrome using confocal microscopy.
The records of all patients with a clinical diagnosis of unilateral ICE syndrome that underwent bilateral confocal microscopy from January 1999 to September 2006 were reviewed. A group of healthy age matched volunteers served as controls. Endothelial cell borders were manually marked and counted by a single examiner. Cell parameters were determined by commercially available software (Nidek CO., Ltd, USA). Patient demographics, endothelial cell density, pleomorphism and polymegathism were assessed.
14 ICE syndrome patients (11 females, 3 males) and 9 controls (7 females, 2 males) met the inclusion criteria. Mean age (±SD) was 53.4 ± 13.1 years and 55.2 ± 13.6 years for ICE patients and controls respectively (p=0.75). The average number of endothelial cells used for calculation and cell density for ICE patients and controls did not differ significantly: 89.1 ± 38.7 and 82.9 ± 21.1 (p=0.666); 2768.4 ± 844.8 and 2615 ± 271.6 (p=0.606) respectively. Percent hexagonal cells (pleomorphism) was 60.5% ± 7.8% in ICE patients and 60% ± 10% of controls (p=0.546). The mean coefficient of variation (polymegathism) was 0.40 ± 0.20 and 0.31 ± 0.06 (p=0.310) for ICE patients and controls respectively.
These results suggest that although there is a difference in endothelial morphometric parameters of the contra-lateral eye of patients with unilateral ICE syndrome compared to controls, these differences did not reach statistical significance.
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