May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Electrophysiologic Changes With Intravitreal Bevacizumab in Patients With Proliferative Diabetic Retinopathy
Author Affiliations & Notes
  • A. Perez Montesinos
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • M. E. Torres-Soriano
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • V. Kon-Jara
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • J. Diaz-Rubio
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • M. Hernandez-Rojas
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • V. Cubas-Lorenzo
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • O. Martinez-Guzman
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • J. Fromow-Guerra
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • H. Quiroz-Mercado
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • J. M. Jimenez-Sierra
    Retina Service, Asociacion para evitar la Ceguera. Hospital Dr. Luis Sanchez Bulnes., Mexico, D.F., Mexico
  • Footnotes
    Commercial Relationships A. Perez Montesinos, None; M.E. Torres-Soriano, None; V. Kon-Jara, None; J. Diaz-Rubio, None; M. Hernandez-Rojas, None; V. Cubas-Lorenzo, None; O. Martinez-Guzman, None; J. Fromow-Guerra, None; H. Quiroz-Mercado, None; J.M. Jimenez-Sierra, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2894. doi:
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    • Get Citation

      A. Perez Montesinos, M. E. Torres-Soriano, V. Kon-Jara, J. Diaz-Rubio, M. Hernandez-Rojas, V. Cubas-Lorenzo, O. Martinez-Guzman, J. Fromow-Guerra, H. Quiroz-Mercado, J. M. Jimenez-Sierra; Electrophysiologic Changes With Intravitreal Bevacizumab in Patients With Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2894.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate the findings in the electroretinographic response in diabetic patients with proliferative diabetic retinopathy after treatment with intravitreal bevacizumab, using standard electroretinogram (st ERG).

Methods:: Twelve patients with proliferative diabetic retinopathy without previous pan-retinal photocoagulation, were treated with intravitreal bevacizumab (2.5mg/0.1cc). Evaluation with st ERG was performed at baseline and ten days after treatment. Best corrected visual acuity and fluorescein angiography were also evaluated.

Results:: All subjects tested had response improvement or stabilization of the st-ERG after treatment. Improvement in rod response after intravitreal bevacizumab resulted statistically significant (p < 0.05).

Conclusions:: Our data suggest that the use of intravitreal bevacizumab results in improvement of scotopic st ERG responses, increasing the amplitude and decreasing the implicit time. This improvement could be correlated with an improvement in retinal perfusion and with a lack of retinal toxicity.

Clinical Trial:: www.clinicaltrials.gov APEC-015

Keywords: retina • electrophysiology: clinical • diabetic retinopathy 
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